The nonspecific metabolic reaction of cells to extreme exposures
- Authors: Inzhevatkin E.V.1, Savchenko A.A.2
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Affiliations:
- Krasnoyarsk Scientific Center, Siberian Branch
- Federal State Budgetary Scientific Institution
- Issue: Vol 43, No 1 (2016)
- Pages: 2-11
- Section: Biochemistry
- URL: https://journals.rcsi.science/1062-3590/article/view/181459
- DOI: https://doi.org/10.1134/S1062359016010064
- ID: 181459
Cite item
Abstract
This work summarizes the authors’ recent investigations into metabolic changes in blood lymphocytes, cancer cells, and hepatocytes during tumor growth from mice with Ehrlich ascites carcinoma. These results were compared with the metabolic changes in hepatocytes from rats after hyperthermia and in lymphocytes from patients with different diseases. It was shown that the extreme conditions induced metabolic changes that were independent of the cell type or the nature of the extreme factor. These changes characterized the metabolic mechanisms of cell adaptation and disadaptation. The concept of the “nonspecific metabolic reaction” of cells to extreme exposures had been introduced.
About the authors
E. V. Inzhevatkin
Krasnoyarsk Scientific Center, Siberian Branch
Author for correspondence.
Email: inscience@mail.ru
Russian Federation, Akademgorodok 50, Krasnoyarsk, 660036
A. A. Savchenko
Federal State Budgetary Scientific Institution
Email: inscience@mail.ru
Russian Federation, ul. Partizana Zheleznyaka 3G, Krasnoyarsk, 660022