Controlling the Permeability of Polyelectrolyte Capsule Shells by Modifying Them with Haematin

Аннотация

The permeability of polyelectrolyte capsule shells is controlled by incorporating a natural hydrophobic pigment, haematin, into them via adsorption from an aqueous ammonia solution. The modification of capsules with the dye has been confirmed by the data of Raman light scattering and the measurements of the ζ potential. The capsules containing haematin in the shells have been characterized by spectrophotometry, atomic force microscopy, and scanning electron microscopy. Time variations in the surface charge, morphology, and thickness of the capsule shells have been discovered. Moreover, a decrease in the permeability of the modified capsule shells with respect to rhodamine 6G has been revealed. Polyelectrolyte capsules containing doxorubicin inside of them and haematin in their shells have been obtained. It has been shown that the drug is not spontaneously released into an aqueous medium over time.