Correlation analysis of interleukin-10 indicators and tumor necrosis factor-alpha as clinical indicators of rehabilitation treatment of postmastectomy lymphedema in patients after complex breast cancer treatment
- 作者: Agranovich N.1, Sivolapova M.2, Kirsanova D.2, Marchenko A.2, Gulieva L.1, Muskhadzhieva R.1, Cнernomazov V.2, Anopchenko A.1
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隶属关系:
- Stavropol State Medical University
- Stavropol Regional Clinical Oncology Center
- 期: 卷 25, 编号 6 (2020)
- 页面: 200-207
- 栏目: Clinical investigations
- URL: https://journals.rcsi.science/1028-9984/article/view/79436
- DOI: https://doi.org/10.17816/1028-9984-2020-25-6-200-207
- ID: 79436
如何引用文章
详细
Background. Cellular immunity and cytotoxic agents are involved in the inflammatory process and tumor cell apoptosis resolution.Background. Cellular immunity and cytotoxic agents are involved in the inflammatory process and tumor cell apoptosis resolution. Endothelial cell apoptosis violation, imbalanced cytokines are considered as one of the contributory factors for postmastectomy lymphedema development.
Aim. To assess the correlation between the interleukin profile (interleukin-10 and tumor necrosis factor-alpha) and clinical indicators of postmastectomy lymphedema in the rehabilitation treatment course after complex breast cancer treatment
Materials and methods. The study involved 50 people aged 40–65 years. The main group consisted of 40 females who underwent a rehabilitation treatment course for postmastectomy lymphedema. The control group consisted of 10 females with a verified breast cancer diagnosis who were preparing for surgical treatment. The statistical analysis determined the differences between the mean values of indicators using the Mann-Whitney U-test and the Wilcoxon T-test. Spearman’s nonparametric correlation analysis was used to determine the relationship between the studied characteristics. Differences between indicators were considered statistically significant at p ≤ 0.05.
Results. The indices of the studied interleukins in the control group are significantly higher than that of the main group. Interleukin-10 remained unchanged in the course of restorative treatment, whereas tumor necrosis factor-alpha increased from 43.72 ± 10 pg/l to 118.94 ± 14.74 pg/l. After the course, a statistically significant correlation (p < 0.05) was found between the levels of the studied interleukins. A positive trend was observed as a result of rehabilitation treatment of postmastectomy lymphedema: the average excess volume in patients of the main group decreased by 38.5%.
Conclusion. Evaluation of interleukin-10 and tumor necrosis factor-alpha in patients with postmastectomy lymphedema allows not only the restorative treatment results assessment and determination of the immune status parameter and damage degree of the vascular endothelium of a particular patient but also prognosis formation of malignant neoplasm development.
作者简介
N. Agranovich
Stavropol State Medical University
Email: ZVS0206@yandex.ru
ORCID iD: 0000-0002-3717-7091
俄罗斯联邦, Stavropol
Margarita Sivolapova
Stavropol Regional Clinical Oncology Center
编辑信件的主要联系方式.
Email: ZVS0206@yandex.ru
ORCID iD: 0000-0002-3224-1584
graduate student of department of policlinic therapy, physiotherapist, oncologist
俄罗斯联邦, StavropolD. Kirsanova
Stavropol Regional Clinical Oncology Center
Email: ZVS0206@yandex.ru
ORCID iD: 0000-0001-5595-6040
俄罗斯联邦, Stavropol
A. Marchenko
Stavropol Regional Clinical Oncology Center
Email: ZVS0206@yandex.ru
俄罗斯联邦, Stavropol
L. Gulieva
Stavropol State Medical University
Email: ZVS0206@yandex.ru
ORCID iD: 0000-0002-0708-0790
俄罗斯联邦, Stavropol
R. Muskhadzhieva
Stavropol State Medical University
Email: ZVS0206@yandex.ru
ORCID iD: 0000-0002-1870-0609
俄罗斯联邦, Stavropol
V. Cнernomazov
Stavropol Regional Clinical Oncology Center
Email: ZVS0206@yandex.ru
俄罗斯联邦, Stavropol
A. Anopchenko
Stavropol State Medical University
Email: ZVS0206@yandex.ru
ORCID iD: 0000-0002-9308-6784
俄罗斯联邦, Stavropol
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