Clinical value of KI-67 index in tumor tissue in patients with stage I and II ovarian cancer


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Prediction of ovarian cancer (EOC) is dependent on a number of clinical, morphological, immunological and molecular biological factors. Thanks to the research findings indicate that Ki-67 is characterized by the most aggressive forms of ovarian cancer - ovarian serous cystadenocarcinoma, and that with a high index of Ki-67 in tumor tissue paired unfavorable prognosis even stage I and II disease, Ki-67 protein can be considered as an adverse molecular prognostic factors of ovarian cancer early stages.

作者简介

Seda Nikogosyan

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

Email: vikakarapetyan@mail.ru
MD, PhD, Dsi 115478, Moscow, Russian Federation

A. Baryshnikov

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

115478, Moscow, Russian Federation

E. Stepanova

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

115478, Moscow, Russian Federation

V. Kuznetsov

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

115478, Moscow, Russian Federation

V. Karapetyan

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

115478, Moscow, Russian Federation

参考

  1. Ефремов Г.Д. Роль иммуногистохимии в диагностике рака предстательной железы. Экспериментальная и клиническая урология. 2011; 1: 50-6.
  2. Имянитов Е.Н. Молекулярные нарушения в опухолях яичников. В кн.: Горбунова В.А., ред. Диагностика и лечение рака яичников. М.: Медицинское информационное агентство; 2011: 15-28.
  3. Козаченко В.П. Клиническая онкология. М.: Медицина. 2005.
  4. Никогосян С.О., Кузнецов В.В. Рак яичников: вопросы диагностики и современные методы лечения. Врач. 2010; 9: 2-9.
  5. Полушкина И.Н. Биомолекулярные маркеры как факторы прогноза при серозном раке яичников III-IV стадии: Дисс.. канд. мед. нук. М.; 2003.
  6. Chan J.K, Tian C., Monk B.J. et al. Prognostic factors for high-risk early-stage epithelial ovarian cancer. Am. J. Cancer. 2008; 112(10): 2202-10.
  7. Kobel M., Kalloger S.E., Boyd N., McKinney S., Mehl E. et al. Ovarian сarcinoma subtypes are different diseases: Implications for biomarker studies. PLoSMed. 2008; 5(12): e232.
  8. Kommoss S., Rochon J., Harter P. et al. Prognostic impact of additional extended surgical procedures in advanced-stage primary ovarian cancer. Ann. Surg. Oncol. 2010 Jan; 17(1): 279-86.
  9. Барышников А.Ю., Шишкин Ю.В. Программированная клеточная смерть (апоптоз). Российский онкологический журнал. 1996; 1: 58-61.
  10. Татосян А.Г. Молекулярно-генетические изменения в злокачественных клетках. В кн.: Заридзе Д.Г., ред. Канцерогенез. М.: Научный мир; 2000: 57-74.
  11. Степанова Е.В., Барышников А.Ю. Никогосян С.О., Кузнецов В.В., Карапетян В.Л. Молекулярно-биологические факторы прогноза рака яичников начальных стадий. Вестник РОНЦ им. Н.Н. Блохина РАМН. 2011; 22(1): 37-41.
  12. Anttila M., Kosma V., Li H. et al. Clinical significance of catenincjllagen IV, and Ki-67 expression in epithelial ovarian cancer. J. Clin. Oncol. 1998, 16: 2591-600.
  13. Harlozinca A., Bar J., Sedlakzek P. et al. Expresssion of p53 protein and Ki-67 reactivity in ovarian neoplasms. Correlation with histopathology. Am. J. Clin. Pathol. 1996; 105(3): 334-40.
  14. Khouja M.H., Baekelandt M., Nesland J.M., Holm R. The clinical importance of Ki-67, p16, p14, and p57 expression in patients with advanced ovarian carcinoma. Int. J. Gynecol. Pathol. 2007; 26(4): 418-25.
  15. Marrack J.R. Nature of antibodies. Nature. 1934; 133: 292-3.
  16. Coons A.H., Creech H.J., Jones R.N. Immunological properties of an antibody containing a fluorescent group. Proc. Soc. Ехр. Biol. (N.Y.). 1941; 47: 200-2.
  17. Coons A.H., Leduc E.H., Connolly J.M. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J. Ехр. Med. 1955; 102: 49-60.
  18. Korkolopoulou P., Vassilipoulos I., Koustantinidou A.E. et al.: The combined valuation of p27 kipl and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients. J. Gynecol. Oncol. 2002; 85(3): 404-14.
  19. Khalifeh I., Munkarah A.R., Schimp V. et al. The impact of c-kit and ki-67 expression on patients prognosis in advanced ovarian serous carcinoma. Int. J. Gynecol. Pathol. 2005; 24(3): 228-34.
  20. Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 2000; 182(3): 311-22.
  21. Penault-Llorca F., Cayre A., Bouchet Mishellany F. et al. Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome. Int. J. Oncol. 2003; 22 (6): 1319-25.
  22. Ojea Calvo A., Mosteiro Cervino M.J., Dominguez Freire F., Alonso Rodrigo A., Rodriguez Iglesias B., Benavente Delgado J. et al. Prognostic factors of prostate cancer: usefulness of Ki- 67 expression in preoperative biopsies. Arch. Esp. Urol. 2004; 57(8): 805-16.
  23. Mulligan J.M., Mai K.T., Parks W., Gerridzen R.G. Proliferating cell nuclear antigen (PCNA) and MIB 1: Markers of locally advanced and biologically aggressive prostate cancer. Can. J. Urol. 1997; 4(3): 422-5.
  24. Rioux-Leclercq N., Leray E., Patard J.J., Lobel B., Guille F. et al. The utility of Ki-67 expression in the differential diagnosis of prostatic intraepithelial neoplasia and ductal adenocarcinoma. Hum. Pathol. 2005; 36(5): 531-5.
  25. Taftachi R., Ayhan A., Ekici S., Ergen A., Ozen H. Proliferating-cell nuclear antigen (PCNA) as an independent prognostic marker in patients after prostatectomy: a comparison of PCNA and Ki-67. Br. J. Urol. Int. 2005; 95(4): 650-4.
  26. Reitmaier M., Rudlowski C., Biersterfeld S. et al. Comparative studies on the biological significance of the marker for proliferation Ki-67 antigen and PCNA in primary ovarian carcinoma. Zbl. Gynakol. 2000; 122(7): 361-7.
  27. Kerner R., Sabo E., Gershoni-Baruch R. et al. Expression of cell cycle regulatory proteins in ovaries prophylactically removed from Jewish Ashkenazi BRCA1 and BRCA2 mutation carriers: correlation with histopathology. Gynecol. Oncol. 2005; 99(2): 367-75.
  28. Harlozinca A., Bar J., Sedlakzek P. et al. Expresssion of p53 protein and Ki-67 reactivity in ovarian neoplasms. Correlation with histopathology. Am. J. Clin. Pathol. 1996; 105(3): 334-40.
  29. Schindlbeck C., Hantschmann R., Zerzer M., Jahni W. et al. Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone Harrow. Int. J. Gynecil. Cancer. 2007; 17(5): 1047-55.
  30. Viale G., Maisonneuve P., Bonoldi E. et al. The combined evaluation of p53 and of Ki-67 (MIB1) labeling index provides independent information on overall survival of ovarian carcinoma patients. Ann. Oncol. 1997; 8(5): 469-76.

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