Email this article Sunitinib - standard second-line therapy of metastatic gastro-intestinal stromal tumors (review of literature and case reports)
- Authors: Meshcheryakov A.A.1, Filonenko D.A1, Petukhova S.V2
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Affiliations:
- N.N. Blokhin Russian Lancer Research Center
- “Central Clinical Hospital with Outpatient Health Center” of the Business Administration for the President of the Russian Federation
- Issue: Vol 20, No 2 (2015)
- Pages: 48-53
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40162
- DOI: https://doi.org/10.17816/onco40162
- ID: 40162
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Abstract
Treatment of gastrointestinal stromal tumors actively developed. Standard second-line treatment of disseminated gastrointestinal stromal tumors is sunitinib (Sutent). Its effectiveness is proven in a randomized, double-blind, multicenter, international phase III trial NCT 00075218. This review summarizes recent data on the epidemiology and diagnosis of the disease, a common approach to the treatment of early and advanced disease, the results of the registration study of sunitinib phase III clinical recommendations to reduce the frequency and severity of adverse events. Particular attention is paid to the factors that are key to achieving the maximum clinical efficacy of sunitinib, namely, prevention and treatment of adverse events, optimizing the dosage regimen and duration of treatment. The article illustrates own clinical observations that demonstrate the efficacy of sunitinib as second-line therapy of disseminated gastrointestinal stromal tumors.
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##article.viewOnOriginalSite##About the authors
Andrey A. Meshcheryakov
N.N. Blokhin Russian Lancer Research Center
Email: a_meshcheryakov@mail.ru
MD, PhD 115478, Moscow, Russian Federation
D. A Filonenko
N.N. Blokhin Russian Lancer Research Center115478, Moscow, Russian Federation
S. V Petukhova
“Central Clinical Hospital with Outpatient Health Center” of the Business Administration for the President of the Russian Federation121359, Moscow, Russian Federation
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