Positron emission tomography, combined with computed tomography, in resistent lesions of gestational trofoblastic tumors topical diagnostics

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Abstract

Introduction. Gestational trophoblastic neoplasias are rare tumors, which consist of about 1% of gynecological cancers. High rate of diagnostic and treatment mistakes leads to late diagnosis, metastatic appearance, resistance to chemotherapy, poor prognosis.

Aim. To demonstrate possibilities of 18F-FDG PET/CT to find resistant lesions of gestational trophoblastic neoplasias.

In the article, we analyze several medical reports to illustrate advantages of 18F-FDG PET/CT for evaluation of resistant gestational trophoblastic neoplasias.

About the authors

L. A. Meshcheriakova

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health

Author for correspondence.
Email: mdnadya@gmail.com
ORCID iD: 0000-0001-8479-3615

MD, PhD, radiologist

Russian Federation, Moscow

A. F. Maslennikov

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health

Email: mdnadya@gmail.com
ORCID iD: 0000-0003-3959-3133
Russian Federation, Moscow

N. A. Meshcheriakova

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health

Email: mdnadya@gmail.com
ORCID iD: 0000-0003-0770-3406
Russian Federation, Moscow

A. I. Pronin

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health

Email: mdnadya@gmail.com
ORCID iD: 0000-0003-1632-351X
Russian Federation, Moscow

M. A. Chekalova

Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency

Email: mdnadya@gmail.com
ORCID iD: 0000-0002-5565-2511
Russian Federation, Moscow

I. G. Komarov

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health

Email: mdnadya@gmail.com
ORCID iD: 0000-0002-3495-5521
Russian Federation, Moscow

References

  1. Meshcheryakova L.A. Gestational trophoblastic disease: diagnostics, treatment and prognosis. Dissertatsiya na soiskanie uchenoy stepeni doktora meditsinskikh nauk. Moscow; 2005. (In Russian)
  2. Meshcheryakova L.A., Kozachenko V.P., Kuznetsov V.V. Gestational trophoblastic disease. In: Kozachenko V.P., red. Klinicheskaya onkoginekologiya. 2-e izd. Moscow: Binom; 2016; 324–68. ( In Russian)
  3. Meshcheryakova L.A. Gestational trophoblastic disease. In: Kaprin A.D., Ashrafyan L.A., Stilidi I.S., red. Natsional’noe rukovodstvo po onkoginekologii. Moscow: GEOTAR-Media; 2019; 273–292. ( In Russian)
  4. Practical recommendations in gestational trophoblastic disease treatment. Spetsvypusk 2. Moscow; 2019; 201˗10. ( In Russian)
  5. Gasanbekova Z.A. Faults in gestational trophoblastic disease diagnostics and treatment. Dissertatsiya na soiskanie uchenoy stepeni kandidata meditsinskikh nauk. Moscow; 2019. ( In Russian)
  6. Numnum T.M., Leath C.A., Straughn J.M. et al. Occult choriocarcinoma discovered by positron emission tomography/computed tomography imaging following a successful pregnancy. Gynecol. Oncol. 2005; 97: 713–5.
  7. Kani K.K., Lee J.N., Dighe M. et al. Gestational trophoblastic disease: multimodality imaging assessment with special emphasis on spectrum of abnormalities and value of imaging in staging and management of disease. Current Problems in Diagnostic Radiology. 2012; 41 (1): 1–10.

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