MANAGEMENT OF SEVERE PERIOPERATIVE BLEEDING IN PATIENTS DURING EXTENSIVE LIVER RESECTIONS FOR COLORECTAL METASTASES


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Abstract

Aim of the study. To estimate an influence of the Cavitron ultrasonic surgical aspirator (CUSA) on intraoperative blood loss. Material and methods. An analysis of 185 cases of extensive liver resections in patients for colorectal liver metastases has been performed. All patients were assigned to CUSA group (n = 56) or clamp crashing group (n = 129). Patients from the first group received regional FOLFOX6 or FOLFOX6 + bevacizumab chemotherapy. Preoperative chemotherapy did not performed for second group of patients. Results. Liver transection with CUSA did not lead to the decline in intraoperative blood loss (p = 0.35). Conclusion. Median intraoperative blood loss was 1065 and 1180 ml respectively. Method for liver transection did not lead to the decline in intraoperative blood loss (p = 0.35). Intraoperative blood loss increases from standard to extensive liver resection (p = 0.0007). Resection of contralateral blood lobe metastases did not lead to statistically significant increase in blood loss as compared with standard mode of the operation (p = 0.005).

About the authors

K. G Mamontov

Altai Branch of N.N. Blokhin Russian Cancer Research Center

Barnaul, 656049, Russian Federation

Sergey L. Khays

Altai Branch of N.N. Blokhin Russian Cancer Research Center

Email: khayss@mail.ru
MD, Researcher of the Department of X-Ray-Surgical Methods of Treatment of the Altai Branch of N.N. Blokhin Russian Cancer Research Center; Barnaul, 656049, Russian Federation Barnaul, 656049, Russian Federation

E. V Varnavskiy

Altai Branch of N.N. Blokhin Russian Cancer Research Center

Barnaul, 656049, Russian Federation

A. K Mamontov

Altai Branch of N.N. Blokhin Russian Cancer Research Center

Barnaul, 656049, Russian Federation

A. F Lazarev

Altai Branch of N.N. Blokhin Russian Cancer Research Center

Barnaul, 656049, Russian Federation

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