Local tissue interleukine profile in breast cancer

Breast cancer ranks first in the structure of oncological diseases in women in Russia and in the World. In recent years there have been numerous reports that the growth and progression of breast cancer and other tumors depend not only on their malignant potential, but also on stromal factors presented in the tumor microenvironment and intercellular interactions. The aim of our study was to evaluate intercellular interactions of the tissues surrounding the tumor, by means of determination of the locally interleukine profile. We have identified interleukine profiles of the axillary fatty tissue from the lesions and subcutaneous fat of the anterior chest wall, located at a maximum distance from the tumors, in stage IIa-IIIb breast cancer patients. As a result we came to a conclusion: the method based on the measurement of IL-1, IL-2, IL-6, IL-10 and а-TNF levels in the tissues and in the blood allows to evaluate the immune processes occurring in the tissues surrounding the tumor; adipose tissue of various areas of breast cancer patients differs significantly according to the level of interleukines, which indicates that different involvement of adipose tissue in various areas of the immune response; there is a dependence of the local immune status of armpit adipose tissue on the expression of ER, PgR, Her2/neu on the surface of breast cancer cells.

breast cancer, adipose tissue, interleukines profile, local immune status