Immunological microenvironment in the clinical outcome of some solid tumors


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Abstract

In our clinical research we studied levels of neutrophils, eosinophils and CD8 T-lymphocytes in stroma and microenvironment of the gastric and colorectal adenocarcinomas, head and neck squamous cell carcinomas (33 patients: 15 with adenocarcinoma and 18 - with head and neck carcinoma). In gastric or colorectal adenocarcinoma expression of neutrophils directly correlates with regional lymph nodes involving, expression of CD8 has inversely correlation with differentiation of the tumor. In head and neck squamous cell carcinoma neutrophils expression inversely correlates with keratinization, CD8 expression has inversely correlation with the size of primary tumor and stage, and has direct correlation with keratinization. This study allows to draw a conclusion about heterogeneity of solid tumors depending on immunology of microenvironment, moreover squamous cell carcinoma of head and neck is more “immunocompetent” structure. Correlation analysis revealed prognostic and predictive value of immunological microenvironment, because showed impact of expression of CD8, neutrophils and eosinophils on clinical outcome of gastric and colorectal adenocarcinomas and squamous cell carcinoma of head and neck.

About the authors

G. M Manikhas

City clinical oncology dispensary; First I. P Pavlov State Medical University of Saint-Petersburg

Saint-Petersburg, 198255, Russain Federation

Svetlana I. Kutukova

City clinical oncology dispensary; First I. P Pavlov State Medical University of Saint-Petersburg

Email: dr.s.kutukova@gmail.com
MD, PhD, oncologist of the chemotherapeutic department (№ 11) of the City Clinical Oncological Dispensary Saint-Petersburg, 198255, Russain Federation

N. P Beliak

City clinical oncology dispensary

Saint-Petersburg, 198255, Russain Federation

G. A Raskin

Russian Scientific Center Of Radiology And Surgical Technology

Saint-Petersburg, 197758, Russian Federation

A. I Yaremenko

First I.P. Pavlov State Medical University of Saint-Petersburg

Saint-Petersburg, 197022, Russian Federation

Yu. V Ivaskova

City clinical oncology dispensary

Saint-Petersburg, 198255, Russain Federation

T. S Ermakova

City clinical oncology dispensary; First I. P Pavlov State Medical University of Saint-Petersburg

Saint-Petersburg, 198255, Russain Federation

S. S Bozhor

First I.P. Pavlov State Medical University of Saint-Petersburg

Saint-Petersburg, 197022, Russian Federation

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