Effect of hyperthermia on the viability and proliferative activity of tumor cells


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Abstract

Introduction. Results of the systemic chemotherapy in the peritoneum canceromatosis are unsatisfactory because of poor penetration of anticancer drugs in serous cavities due to the presence ofperitoneal-plasma barrier. One of the possible ways to enhance the action cytostatic agents is the use of chemotherapy and hyperthermia, which, according to some data, has an own cytotoxic effect. The purpose of the study. The study of the effect ofdifferent modes of hyperthermia on the physiological activity of transplantable lines of tumor and non-transformed cells. Results. Analysis of the impact of hyperthermia on the physiological activity of transplantable lines of tumor and the non-transformed cells in vitro and in vivo studies demonstrated that along with the gain in the level and time of the temperature exposure as the degree of damage as tumor cell mortality rate increases. In this study the most effective treatment was as follows: the temperature is above 45°C with the exposure of more than 2 hours, which is difficult to achieve in practice due to the limited tolerance of healthy tissues. Conclusion. With the use of hyperthermia in monoregimen it is not possible to achieve effective levels of the temperature impact, which could hardly have a significant inhibitory effect on tumor cells.

About the authors

N. Yu Anisimova

Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

M. V Kiselevskiy

Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

Amir G. Abdullaev

Blokhin Russian Cancer Research Center

Email: amirdo@mail.ru
MD, PhD, Senior researcher of the Thoracic Department of the Research Institute of Clinical Oncology Moscow, 115478, Russian Federation

N. V Malakhova

Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

S. M Sitdikova

Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

B. E Polotskiy

Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

M. M Davydov

Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

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