Email this article Prior malignant neoplasms as a risk factor for the second cancer in a cohort of employees of enterprises of the nuclear industrial complex
- Authors: Osipov M.V.1, Sokolnikov M.E1
-
Affiliations:
- Southern Urals Biophysics Institute
- Issue: Vol 21, No 4 (2016)
- Pages: 190-194
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40303
- DOI: https://doi.org/10.18821/1028-9984-2016-214-190-194
- ID: 40303
Cite item
Full Text
Abstract
Purpose. Assessment of the persistence ofprevious malignancy as a risk factor for the detection of subsequent cancer in a cohort of nuclear workers. Material and methods. Retrospective cohort study with 60 years of follow-up on 22.373 workers of nuclear facility recruited from 1948 to 2008, with the use of data on individual external and internal dosimetry, and information about cancer incidence and mortality rate due to cancer neoplasma (CN). Results. In the studied cohort second and subsequent CN were diagnosed in 6,4% cases, out of them 92,4% were cases of second cancers, in other cases the number of CN was more than two. 8% of cases ofprimary multiple cancers were presented by non-melanoma skin cancers (NMSC). Mean age ofpersons with more than one diagnosis of cancer was 67 years. The relative risk of the detection of second CN (excepting NMSC) among persons with already diagnosed previous cancer was about 4 times higher in comparison in persons without diagnosis of solid cancer. Discussion. Detected solid tumors were proposed to be diagnosed in the order of their occurrence, but it cannot be excluded that in different latent periods of solid cancers of various localization this condition may fail to comply. The radiotherapy and the effect of dispanserization could play the essential role in the occurrence of second and subsequent cancers when the possibility of the detection of CN in a patient being under dispensary observation by oncologist is higher than in persons without dispensary observation. At the same time, the one possibility of carcinogenic effect of the first malignancy must not be excluded. Conclusions. Cancer risk among nuclear workers who have previous malignancy was 4 times higher in comparison with workers who had no previous diagnosis of cancer.
Full Text
##article.viewOnOriginalSite##About the authors
Mikhail V. Osipov
Southern Urals Biophysics Institute
Email: ferrum76@mail.ru
MD, Junior researcher of the Laboratory of radiation epidemiology Ozyorsk, 456790, Russian Federation
M. E Sokolnikov
Southern Urals Biophysics InstituteOzyorsk, 456790, Russian Federation
References
- Каприн А.Д., Старинский В.В., Петрова Г.В., ред. Злокачественные новообразования в России в 2013 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена - филиал ФГБУ «ФМИЦ им. П.А. Герцена» Минздрава России. 2015. ISBN 978-5-85502-205-6.
- Curtis R.E., Freedman D.M., Ron E., Ries L.A.G., Hacker D.G., Edwards B.K. et al., Eds. New Malignancies Among Cancer Survivors: SEER Cancer Registries, 1973-2000. National Cancer Institute. NIH Publ. No. 05-5302. Bethesda; 2006.
- Джойнер М.С., Ван дер Когель О.Дж., ред. Основы клинической радиобиологии: Пер. с англ. М.: БИНОМ, Лаборатория знаний; 2013.
- Sokolnikov M.E., Gilbert E.S., Preston D.L., Ron E., Shilnikova N.S. et al. Lung, liver and bone cancer mortality in Mayak workers. Int. J. Cancer. 2008; 123: 905-11.
- Осипов М.В., Сокольников М.Э. Оценка риска смертности от злокачественных новообразований органов желудочно-кишечного тракта у работников ПО «Маяк». Вопросы радиационной безопасности. 2014; (1): 76-83.
- Koshurnikova N.A., Shilnikova N.S., Okatenko P.V. Characteristics of the Cohort of Workers at the Mayak Nuclear Complex. Radiat. Res. 1999; 152: 352-62.
- Khokhryakov V.V., Khokhryakov V.F., Suslova K.G. et al. Mayak Worker Dosimetry System 2008 (MWDS-2008): Assessment of internal dose from measurement results of plutonium activity in urine. Hlth Phys. 2013; 104 (4): 366-78.
- Preston D.L. Epicure User’s Guide. USA.
- Osipov M.V. An approach to assess the carcinogenic risk from medical exposure in «Mayak» worker cohort. In: Radioactive Sources and Radiation Exposure Effects on the Mayak PA Workers and Population Living in the Area of Nuclear Facility Influence. Chelyabinsk: Chelyabinsk Publishing House; 2014; VI: 110-20.
- Осипов М.В., Сокольников М.Э. Проблемы оценки канцерогенного риска медицинского облучения в когорте персонала предприятия ядерно-промышленного комплекса. Медицинская радиология и радиационная безопасность. 2015; 60 (6): 60-6.
Supplementary files
