Female reproductive system tumors with Merkel cell phenotype


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Abstract

Diagnostics and treatment of female reproductive system tumors with Merkel cell phenotype, rare aggressive tumors with dismal prognosis, is under consideration in this article. Only 20 cases of Merkel cell vulvar carcinoma and 1 case of Merkel cell vagina cancer were described in the literature. Diagnostics must include immunohistochemical analysis, as expression of cytokeratine 20 proves to be the most typical factor. Polyomavirus infection is believed to be associated with the disease pathogenesis. No treatment standards were accepted due to the rarity of the disease. Considering the data on tumor radiosensitivity, the treatment must include radio- or chemoradiotherapy.

About the authors

Seda O. Nikogosyan

N.N. Blokhin Russian Cancer Research Center

Email: zagamedik@mail.ru
MD, PhD, DSc, Leading researcher of the Gynecological Department of the Research Institute of Clinical Oncology Moscow, 115478, Russian Federation

T. Sh Tagibova

N.N. Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

V. V Kuznetsov

N.N. Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

O. A Anurova

N.N. Blokhin Russian Cancer Research Center

Moscow, 115478, Russian Federation

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