Endothelial dysfunction and results of its correction at gastric neoplasm
- Authors: Olzhayev S.T.1, Shoykhet Y.N2,3, Lazarev A.F2,3
-
Affiliations:
- Almaty regional oncologic dispensary
- Altai State Medical University
- N.N. Blokhin Russian Cancer Research Center
- Issue: Vol 20, No 5 (2015)
- Pages: 19-22
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40188
- DOI: https://doi.org/10.17816/onco40188
- ID: 40188
Cite item
Full Text
Abstract
A complex examination of 122 patients with II and III stages of neoplasms were carried out for the purpose of definition of results of correction of disturbances of endothelial functions in operated patients with gastric cancer. All patients were exposed to radical surgical treatment. Endothelium function indicators and contents of circulating endothelial cells were studied. It is revealed that application of L-arginine and ACE inhibitor provides decrease in degree of endothelial dysfunction and damages an endothelium that correlates with decrease in frequency of postoperative complications, late complications in the form of development of recurrence and metastasises and mortality.
Full Text
##article.viewOnOriginalSite##About the authors
Sayakhat T. Olzhayev
Almaty regional oncologic dispensary
Email: s.olzhayev20@gmail.com
MD, PhD 050007, Almaty, The Republic of Kazakhstan
Ya. N Shoykhet
Altai State Medical University; N.N. Blokhin Russian Cancer Research CenterAltai Branch of N.N. Blokhin Russian Cancer Research Center 656038, Barnaul, Russian Federation
A. F Lazarev
Altai State Medical University; N.N. Blokhin Russian Cancer Research CenterAltai Branch of N.N. Blokhin Russian Cancer Research Center 656038, Barnaul, Russian Federation
References
- Абелев Г.И., Эрайзер Т.Л. На пути к пониманию природы рака. Биохимия. 2008;73 (5): 605-18.
- Кубышкин В.А., Вишневский В.А. Рак поджелудочной железы. М.: Медпрактика-М; 2003.
- Bernardini S., Fauconnet S., Chabannes E., Henry P.C. et al. Serum levels of vascular endothelial growth factor as a prognostic factor in bladder cancer. J. Urol. 2001; 166: 1275-9.
- Rajendran P., Rengarajan T., Thangavel J. et al. The vascular endothelium and human diseases. Int. J. Biol. Sci. 2013; 9 (10): 1057-69.
- Ена И.И., Шаназаров Е.А. Современные подходы к хирургическому лечению рака желудка. Фундаментальные исследования. 2011; 10: 204-11.
- Куликов Е.П., Загадаев А.П. Комбинированные операции при раке желудка. Российский медико-биологический вестник им. акад. И.П. Павлова. 2009; 11: 161-9.
- Saka M., Morita S., Fukagawa T., Katai H. Present and future status of gastric cancer surgery. Jpn J. Clin. Oncol. 2011; 41 (3): 307-13.
- Головченко Ю.И., Трещинская М.А. Обзор современных представлений об эндотелиальной дисфункции. Consilium Medicum Ukraina. 2008; 11: 17-25.
- Efron B., Tibshirani R.J. An Introduction to the Bootstrap. New York: Chapman & Hall, Software; 1993.
- Goon P.K., Boos C.J., Stonelake P.S., Lip G.Y. Circulating endothelial cells in malignant disease. Future Oncol. 2005; 1 (6): 813-20.