Research of topoisomerase A.F. lia activity in conjunction with clinical and morphological parameters and proliferation (to identify argyrophilic proteins of nucleolar organizer regions and antigen Ki-67) in squamous cell carcinoma of the lung


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Abstract

Topoisomerase IIα (TopoIIα), argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR) and antigen Ki-67 in squamous cell carcinoma of the lung were investigated. Defined Tumors with low and high TopoIIα, Ag-NOR and Ki-67 were defined. TopoIIα had a relationship with clinical and morphological parameters (value T, greatest dimension, stage of disease and tumor differentiation) and proliferation markers (Ag-NOR, Ki-67). Survival of patients with squamous cell carcinoma of the lung with low content of TopoIIα is better as compared with high content of TopoIIα. Survival of patients depends on the mutual content of TopoIIα and clinical and morphological parameters (value N, stage of disease), proliferation markers (Ag-NOR). TopoIIα and Ag-NOR are independent prognostic factors. Mutual research of TopoIIα with clinical and morphological parameters and Ag-NOR has prognostic value in squamous cell carcinoma of the lung.

About the authors

D. S Kobyakov

Kogalym City Hospital

Email: dskob@yandex.ru
канд. мед. наук, зав. патологоанатомическим отд-нием 628481, Kogalym, Russian Federation

E. Yu Bychkova

Altai branch N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

A. M Avdalyan

Altai branch N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

I. P Bobrov

Altai Medical University

656038, Barnaul, Russian Federation

S. A. Lazarev

Altai branch N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

N. M Kruglova

Altai branch N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

E. X Lushnikova

Scientific Research Institute of Regional Pathology and Pathomorphology of the Siberia Region under the Russian Academy of Medical Sciences

630117, Novosibirsk, Russian Federation

A. F Lazarev

Altai branch N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

L. M Nepomnyashchikh

Scientific Research Institute of Regional Pathology and Pathomorphology of the Siberia Region under the Russian Academy of Medical Sciences

630117, Novosibirsk, Russian Federation

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