Extensive liver resection with preoperative chemotherapy for colorectal metastases with high risk of complications


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Abstract

Objective: to study influence of preoperative chemotherapy on postoperative complications rate. Material and methods: an analysis of 455 cases of extensive liver resection. 229 (56%) patients didn’t receive neoadjuvant chemotherapy, 176 (44%) - received preoperative chemotherapy. 216 (53%) patients had bilobar lesions, 156 (39%) - had multiple metastases, 168 (42%) - had synchronous metastases, 237 (58%) - had metachronous metastases. 60 (15%) patients in addition to liver lesions, had been resected for extrahepatic metastases. Results: bevacizumab inckusion to preoperative regional chemotherapy did not lead to increase of postoperative complication rate. Conclusion: Postoperative complication rate didn’t significantly differ in all groups of treatment, regardless of liver resection volume. Extension of liver resection from standard hepatectomy to extensive, leads to statistically significant increase of acute hepatic failure. Acute hepatic failure takes the first place among complications (21%).

About the authors

Yu. I Patyutko

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

115478, Moscow

K. G Mamontov

Russian Federation; 2Altai branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

Email: mamontovkg@mail.ru
канд. мед. наук, зав. отд-нием рентгенохирургических методов диагностики и лечения злокачественных опухолей 656049, Barnaul, Russian Federation

A. G Kotelnikov

N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

115478, Moscow

A. A Ponomarenko

State Scientific Center of Coloproctology

123423, Moscow, Russian Federation

A. F Lazarev

Russian Federation; 2Altai branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

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