Email this article Extensive liver resection with preoperative regional chemotherapy for colorectal metastases in patients with high risk of blood loss
- Authors: Lazarev A.F1, Mamontov K.G1, Kotelnikov A.G2, Lubennikov V.A1, Khays S.L1
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Affiliations:
- Altai branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
- N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
- Issue: Vol 19, No 1 (2014)
- Pages: 4-7
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/40017
- DOI: https://doi.org/10.17816/onco40017
- ID: 40017
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Abstract
Objective: to study influence of regional chemo- and biotherapy on intraoperative blood loss. Materials and methods: An analysis of 122 cases of extensive liver resection accompanied with regional chemotherapy in colorectal metastases patients has been performed. 69 (57%) of them had bilobar lesions, 58 (48%) - had multiple metastases, 27 (22%) - had been resected for extrahepatic metastases. Results: bevacizumab inclusion in preoperative regional chemotherapy did not lead to increase of intraoperative blood loss. Conclusion: Median intraoperative blood loss was 1200 ml in both groups. Up to 6 courses of preoperative antitumor therapy, regardless of route of drug introduction did not increase blood loss. Intraoperative blood loss increases from standard to extended liver resection. Resection of contralateral lobe metastases did not lead to statistically significant increase in blood loss as compared with standard operation.
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##article.viewOnOriginalSite##About the authors
A. F Lazarev
Altai branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences656049, Barnaul, Russian Federation
K. G Mamontov
Altai branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
Email: mamontovkg@mail.ru
канд. мед. наук, зав. отд-нием рентгенохирургических методов диагностики и лечения злокачественных опухолей 656049, Barnaul, Russian Federation
A. G Kotelnikov
N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences115478, Moscow, Russian Federation
V. A Lubennikov
Altai branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences656049, Barnaul, Russian Federation
S. L Khays
Altai branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences656049, Barnaul, Russian Federation
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