Email this article CHANGES IN HEMOSTATIC SYSTEM OF CERTAIN MALIGNANT TUMORS
- Authors: Shilova A.N1, Lazarev A.F2, Karmadonova N.A1, Kudrjavtsev A.S1, Anikeeva O.Y.1
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Affiliations:
- Academician E.N. Meshalkin Novosibirsk Research Institute of Blood Circulation Pathology
- Altay branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
- Issue: Vol 18, No 4 (2013)
- Pages: 9-11
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/39984
- DOI: https://doi.org/10.17816/onco39984
- ID: 39984
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Abstract
The parameters of coagulation hemostasis in 37 patients with gastric cancer, 65 patients with colon cancer, 17 patients with prostate cancer and in 8 patients with lung cancer were analyzed. The aggregation of platelets in 119 patients with tumors of the breast, 17 — stomach cancer, 11 — colon cancer, 17 — prostate cancer and 8 — lung cancer also were analyzed. It was found that cancer patients have hyperthrombinemia, hyperfibrinogenemia, violation of the protein C system, reduction of the antithrombin III concentration, increase of induced platelet aggregation, which contributes to the formation of the thrombophilic status in cancer patients, is significant in the progression of the tumor and its metastasis. The use of anticoagulants and antiplatelets by these patients can not only lead to a decrease in the risk of thrombotic complications, but also to improve the survival of cancer patients.
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##article.viewOnOriginalSite##About the authors
A. N Shilova
Academician E.N. Meshalkin Novosibirsk Research Institute of Blood Circulation Pathology630055, Novosibirsk, Russian Federation
A. F Lazarev
Altay branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences656049, Barnaul, Russian Federation
N. A Karmadonova
Academician E.N. Meshalkin Novosibirsk Research Institute of Blood Circulation Pathology630055, Novosibirsk, Russian Federation
A. S Kudrjavtsev
Academician E.N. Meshalkin Novosibirsk Research Institute of Blood Circulation Pathology630055, Novosibirsk, Russian Federation
O. Yu Anikeeva
Academician E.N. Meshalkin Novosibirsk Research Institute of Blood Circulation Pathology630055, Novosibirsk, Russian Federation
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