Email this article DEVELOPMENT OF INTRAVENOUS ADMINISTRATION OF L-LYSINE-ALPHA-OXIDASE FROM TRICHODERMA CF. AUREOVIRIDE RIFAI BKMF-4268 REGIME CONTROLLED BY SAFETY AND EFFICACY OF TREATMENT
- Authors: Pokrovsky V.S1, Treshalina E.M1, Lukasheva E.V2, Sedakova L.A1
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Affiliations:
- N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences
- People’s Friendship University
- Issue: Vol 18, No 2 (2013)
- Pages: 10-14
- Section: Articles
- URL: https://journals.rcsi.science/1028-9984/article/view/39944
- DOI: https://doi.org/10.17816/onco39944
- ID: 39944
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Abstract
Various doses and modes of intravenous L-lysine-alpha-oxidase application on tumor models in mice under the control of efficacy and tolerability have been studied. Optimal choice scheme provides introduction of the first relatively high starting dose and subsequent maintenance doses comprising А or % of the first ("discrete" mode). The efficiency and an acceptable tolerability has been shown during "discrete" 5-fold treatment course with intravenous cumulative doses of 450-550 U/kg. By treating L-lysine-alpha-oxidase in the "discrete" mode following tumor-bearing mice have been sensitive: breast adenocarcinoma Sa755, B16 melanoma, adenocarcinoma of the colon AKATOL, cervical cancer, cervical 5, epidermoid carcinoma and Lewis lung plasmacytoma CI-406 (TROmax = 57-92%).
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##article.viewOnOriginalSite##About the authors
V. S Pokrovsky
N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences
Email: vadimpokrovsky@yandex.ru.
канд. мед. наук, ст. науч. сотр. лаб. комбинированной терапии опухо- лей
E. M Treshalina
N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences
E. V Lukasheva
People’s Friendship University
L. A Sedakova
N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences
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