High expression of CD8+ T-lymphocytes in the peritumoral zone of renal cancer as a factor of unfavorable prognosis
- Authors: Bobrov I.P.1, Lazarev A.F.1, Cherdantseva T.M.2, Klimachev I.V.1, Klimachev V.V.1, Myadelets M.N.1, Lepilov A.V.1, Dolgatov A.Y.1, Korsikov N.A.1, Dolgatova E.S.1, Lushnikova E.L.3, Bakarev M.A.3
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Affiliations:
- Altai State Medical University
- Ryazan State Medical University named after Academician I.P. Pavlov
- Institute of Molecular Pathology and Pathomorphology of the Federal Research Center for Fundamental and Translational Medicine
- Issue: Vol 27, No 3 (2022)
- Pages: 97-105
- Section: Clinical investigations
- URL: https://journals.rcsi.science/1028-9984/article/view/253245
- DOI: https://doi.org/10.17816/onco115219
- ID: 253245
Cite item
Abstract
AIM: To evaluate the prognostic value of quantitative CD8+ T-lymphocyte counts in the peritumorotic zone of renal cell cancer.
MATERIAL AND METHODS: The material of 74 patients after operative treatment for renal cell carcinoma with complete 5-year follow-up was retrospectively analyzed. Of the 74 patients, 56 were alive by the 5-year follow-up, and 18 had died of cancer. After immunohistochemical staining, CD8+ T-lymphocyte distribution density in the peritumorotic zone of carcinomas was determined in 3 representative fields of view at ×400 magnification and correlated with the clinicopathological characteristics of neoplasms and overall 5-year patient survival rate.
RESULTS: The high level of CD8+ T-lymphocyte infiltration in the peritumoral zone of carcinomas was seen in stages III–IV of the disease (p=0.0000001), in tumors >7 cm (p=0.0000001), in Fuhrman grade III–IV anaplasia (p=0.001), in metastases (p=0.0000001) and in the shorter total survival rate of patients (p=0.0003). High CD8+ T-lymphocyte count was also observed in men (p=0.001) and in cases of unclassified cancer.
CONCLUSION: In the light of the need to search for new prognostic criteria in renal cancer, we conclude that a high level of peritumorous zone infiltration by CD8+ T-lymphocytes is an unfavorable prognostic factor. Assessment of peritumorous zone infiltration by CD8+ T-lymphocytes may serve as an additional prognostic factor in renal cell carcinoma.
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##article.viewOnOriginalSite##About the authors
Igor P. Bobrov
Altai State Medical University
Author for correspondence.
Email: ig.bobrov2010@yandex.ru
ORCID iD: 0000-0001-9097-6733
SPIN-code: 2375-1427
MD, Dr. Sci (Med.), Professor
Russian Federation, BarnaulAlexander F. Lazarev
Altai State Medical University
Email: lazarev@arzs.ru
ORCID iD: 0000-0003-1080-5294
SPIN-code: 1161-8387
MD, Dr. Sci. (Med.), Professor
Russian Federation, BarnaulTatyana M. Cherdantseva
Ryazan State Medical University named after Academician I.P. Pavlov
Email: cherdan.morf@yandex.ru
ORCID iD: 0000-0002-7292-4996
SPIN-code: 3773-8785
MD, Dr. Sci. (Med.), Associate Professor
Russian Federation, RyazanIlya V. Klimachev
Altai State Medical University
Email: k0222@yandex.ru
ORCID iD: 0000-0001-9889-9517
MD
Russian Federation, BarnaulVladimir V. Klimachev
Altai State Medical University
Email: pathology_agmu@mail.ru
ORCID iD: 0000-0003-1586-252X
SPIN-code: 8120-3059
MD, Dr. Sci. (Med.), Professor
Russian Federation, BarnaulMikhail N. Myadelets
Altai State Medical University
Email: pathology_agmu@mail.ru
ORCID iD: 0000-0003-3256-6706
MD, Cand. Sci. (Med.)
Russian Federation, BarnaulAlexander V. Lepilov
Altai State Medical University
Email: lepilov@list.ru
ORCID iD: 0000-0003-2477-4687
SPIN-code: 7516-0963
MD, Dr. Sci. (Med.), Professor
Russian Federation, BarnaulAndrey Yu. Dolgatov
Altai State Medical University
Email: adolgatov@yandex.ru
ORCID iD: 0000-0002-7677-4622
SPIN-code: 2804-0011
MD, Cand. Sci. (Med.), Associate Professor
Russian Federation, BarnaulNikolay A. Korsikov
Altai State Medical University
Email: nikkor94knaagmu@yandex.ru
ORCID iD: 0000-0002-0094-4656
Russian Federation, Barnaul
Elena S. Dolgatova
Altai State Medical University
Email: esdol82@yandex.ru
ORCID iD: 0000-0002-6678-4472
Russian Federation, Barnaul
Elena L. Lushnikova
Institute of Molecular Pathology and Pathomorphology of the Federal Research Center for Fundamental and Translational Medicine
Email: pathol@inbox.ru
ORCID iD: 0000-0002-2614-8690
SPIN-code: 3310-1175
MD, Dr. Sci. (Med.), Professor
Russian Federation, NovosibirskMaxim A. Bakarev
Institute of Molecular Pathology and Pathomorphology of the Federal Research Center for Fundamental and Translational Medicine
Email: pathol@inbox.ru
ORCID iD: 0000-0002-9614-592X
SPIN-code: 3630-9977
MD, Dr. Sci. (Med.), Professor
Russian Federation, NovosibirskReferences
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