Lobular carcinomas of the breast: cytological diagnostics

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Abstract

AIMS: To estimate potentialities of cytological diagnostics of different types of lobular carcinomas of the breast while outpatient examination.

MATERIALS AND METHODS: The data of cytological investigations of 444 patients with carcinoma, which were detected by fine-needle aspiration biopsy, were studied. Traditional cytological diagnostics, as well as the liquid-based technique of preparation of patterns were used, staining of patterns according to the Pappenheim and Papanicolaou methods. A standard protocol for immunocytochemical reactions was used.

RESULTS: Lobular carcinoma was detected in 15 patients. Types of lobular carcinomas were verified by cytological method were retrospectively identified.

Classical, solid and tubular types of lobular carcinoma (n=7,46.7%; n=5,33.3%; n=1,6.7%) differed from unspecified breast carcinomas. In the classical type, vacuoles with a target-like inclusion (probably a drop of mucin) were a significant feature. In the solid type, the absence of complexes with a large number of separately located similar tumor cells was noticed. The tubular type was distinguished by the presence of tubular structures. The liquid-based technique helps to differentiate lobular and unspecified carcinoma using an immunocytochemical reaction with E-cadherin.

CONCLUSION: The results of the study indicate that lobular carcinomas of the breast are 3.4% of all breast carcinomas. Taking into consideration the differences in prognosis, it is important to differentiate between lobular and unspecified ductal carcinoma at the outpatient level of diagnostics, as this is deciding for treatment strategy choice.

About the authors

Ol’ga G. Grigoruk

Altai Regional Oncological Dispensary; Altai State Medical University

Email: cytolakod@rambler.ru
ORCID iD: 0000-0001-9981-2348
SPIN-code: 7250-6259

Dr. Sci. (Biol.), Associate Professor

Russian Federation, Barnaul; Barnaul

Tat’jana A. Moskvina

Altai Regional Oncological Dispensary

Email: tanhellita2010@bk.ru

MD

Russian Federation, Barnaul

Larisa M. Bazulina

Altai Regional Oncological Dispensary

Author for correspondence.
Email: lardoc69@mail.ru
ORCID iD: 0000-0002-7222-0657

MD

Russian Federation, Barnaul

Tat’jana V. Sinkina

Altai Regional Oncological Dispensary

Email: tatyanasin@mail.ru

MD, Cand. Sci. (Med.)

Russian Federation, Barnaul

Igor’ V. Vihljanov

Altai Regional Oncological Dispensary

Email: akod@zdravalt.ru

MD, Dr. Sci. (Med.)

Russian Federation, Barnaul

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Supplementary files

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2. Fig. 1. Lobular carcinoma of the breast, classical type. There are vacuoles with a target-like inclusion in the cytoplasm of tumor cells. Pappenheim staining. ×1000.

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3. Рис. 2. Дольковая карцинома молочной железы, классический вариант. Жидкостная цитология. Окрашивание по Папаниколау. ×200.

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4. Рис. 3. Дольковая карцинома молочной железы, солидный вариант. Раздельно лежащие опухолевые клетки, не формирующие комплексов. В одной клетке отмечен митоз. Окрашивание по Паппенгейму. ×1000.

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5. Рис 4. Дольковая карцинома молочной железы, тубулярный вариант. Отмечена тубулярная структура. Окрашивание по Паппенгейму. ×1000.

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6. Рис. 5. Дольковая карцинома молочной железы, смешанный вариант. Отмечен признак мелкогранулированной цитоплазмы, который характерен для опухоли с нейроэндокринной дифференцировкой. Окрашивание по Паппенгейму. ×1000.

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7. Рис. 6. Неспецифицированная карцинома молочной железы. Жидкостная цитология. Позитивная иммуноцитохимическая реакция на Е-кадгерин. ×400.

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Copyright (c) 2023 Григорук О.Г., Москвина Т.А., Баулина Л.М., Синкина Т.В., Вихлянов И.В.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


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