Effect of interval hypoxytherapy on the immune status of hypertensive patients

I. Kh. Borukaeva; Борукаева И. Х.; Z. Kh. Abazova; Абазова З. Х.; A. B. Ivanov; Иванов А. Б.; K. Yu. Shkhagumov; Шхагумов К. Ю.; F. V. Shavaeva; Шаваева Ф. В.; A. A. Molov; Молов А. А.; I. K. Tkhabisimova; Тхабисимова И. К.; T. B. Kipkeeva; Кипкеева Т. Б.; A. G. Shokueva; Шокуева А. Г.; S. M. Ashagre; Ашагре С. М.; D. R. Ligidova; Лигидова Д. Р.; A. M. Kugotov; Куготов А. М.

doi:10.46235/1028-7221-16833-EOI

Effect of interval hypoxytherapy on the immune status of hypertensive patients

作者: Borukaeva I.K.¹, Abazova Z.K.¹, Ivanov A.B.¹, Shkhagumov K.Y.¹, Shavaeva F.V.¹, Molov A.A.¹, Tkhabisimova I.K.¹, Kipkeeva T.B.¹, Shokueva A.G.¹, Ashagre S.M.¹, Ligidova D.R.¹, Kugotov A.M.²
隶属关系:
1. Kh. Berbekov Kabardino-Balkarian State University
2. I. Sechenov First Moscow State Medical University (Sechenov University)
期: 卷 27, 编号 2 (2024)
页面: 273-280
栏目: SHORT COMMUNICATIONS
URL: https://journals.rcsi.science/1028-7221/article/view/263687
DOI: https://doi.org/10.46235/1028-7221-16833-EOI
ID: 263687

如何引用文章

全文:

详细
全文:
作者简介
参考
补充文件
统计

详细

In recent years, the role of sluggish nonspecific inflammation in the pathogenesis of hypertension has been proven. Oxidative stress that develops in hypertension leads to damage of endothelial glycocalyx with impaired barrier and adaptive functions of endothelium. Activation of transcription factor NF-kB leads to increased synthesis of free oxygen radicals, adhesion molecules (VCAM-1, ICAM-1, P-selectin, E-selectin) and proinflammatory cytokines (TNFα, IL-1, IL-6), triggering the inflammatory process in the endothelium. Modern antihypertensive drugs, affecting various pathogenetic mechanisms of arterial hypertension development, do not fully affect the immune component of arterial hypertension. Therefore, the search for various methods affecting the immunologic reactivity of hypertensive patients remains relevant in our time.

The aim of the study was to reveal the effect of interval hypoxytherapy on the state of immunologic reactivity of patients with hypertension stage I.

One hundred seventy male patients of 30-45 years old (mean age 38.36±1.64 years) with hypertension stage I (n = 170) who underwent combined treatment including drug therapy and normobaric interval hypoxic therapy in hypoxia-normoxia mode (oxygen content in hypoxic gas mixture was 20.9%) were examined. Indices of redox status and immunologic reactivity before and after interval hypoxytherapy were studied.

Having a significant antioxidant effect, interval hypoxytherapy led to the subsidence of oxidative stress, which was indicated by an increase in the activity of superoxide dismutase and glutathione peroxidase in blood erythrocytes and a decrease in the content of malonic dialdehyde in blood as a result of a decrease in the generation of free oxygen radicals and suppression of lipid peroxidation processes. Interval hypoxytherapy resulted in a statistically significant increase in the initially decreased content of CD3⁺T lymphocytes (p < 0.05), CD3⁺CD4⁺T lymphocytes (p < 0.02), CD3⁺CD8⁺T lymphocytes (p < 0.02). Initially increased number of B-lymphocytes CD19⁺, CD16⁺ lymphocytes, CD95⁺ lymphocytes significantly decreased. An important result of interval hypoxytherapy was a pronounced anti-inflammatory effect: statistically significant decrease in the content of pro-inflammatory interleukins IL-1β (p < 0.02), IL-6 (p < 0.01) and increase in the content of anti-inflammatory cytokines IL-4 (p < 0.005) and IL-10 (p < 0.005), which led to the subsidence of sluggish nonspecific inflammation.

Suppression of oxidative stress and normalization of immunological reactivity of hypertensive patients after interval hypoxytherapy led to the subsidence of sluggish nonspecific inflammation, reduction of endothelial dysfunction and restoration of the structure and tone of the vascular wall with a decrease in blood pressure and improvement of the clinical course of hypertension.

关键词

hypertension, interval hypoxic therapy, immune status, endothelial dysfunction, immunopathologic nonspecific inflammation, inflammatory

全文:

6^th-Year Student

俄罗斯联邦, Moscow

参考

Абазова З.Х., Шибзухова Л.А., Борукаева И.Х., Шибзухов Т.А., Борукаева Л.А. Гипокситерапия в коррекции неврологических нарушений у детей и подростков с аутоиммунным тиреодитом // Российский вестник перинатологии и педиатрии, 2020. Т. 65, № 4. С. 321. [Abazova Z.Kh., Shibzukhova L.A., Borukaeva I. Kh., Shibzukhov T.A., Borukaeva L.A. Hypoxytherapy in correction of neurological disorders in children and adolescents with autoimmune thyroiditis. Rossiyskiy vestnik perinatologii i pediatrii = Russian Bulletin of Perinatology and Pediatrics, 2020, Vol. 65, no. 4, p. 321. (In Russ.)]
Амирова А.Р., Искандарова Л.Р., Мингазетдинова Л.Н. Иммунная система как предиктор эндотелиальной дисфункции при артериальной гипертонии с метаболическими нарушениями // Фундаментальные исследования, 2006. № 5. С. 92-93. [Amirova A.R., Iskandarova L.R., Mingazetdinova L.N. Immune system as a predictor of endothelial dysfunction in arterial hypertension with metabolic disorders. Fundamentalnyye issledovaniya = Fundamental Research, 2006, no. 5, pp. 92-93. (In Russ.)]
Барсуков А.В., Сеидова А.Ю., Гордиенко А.В., Сергеев А.И., Лейчинский С.В. Гипертоническая болезнь и хроническая сердечная недостаточность с сохраненной сократительной способностью левого желудочка: фокус на гендер-специфические особенности провоспалительного статуса // Артериальная гипертензия, 2017. Т. 23, № 5. С. 457-467. [Barsukov A.V., Seidova A.Yu., Gordienko A.V., Sergeev A.I., Leychinsky S.V. Hypertension and chronic heart failure with preserved left ventricular ejection fraction: focus on gender-specific features of the proinflammatory status. Arterialnaya gipertenziya = Arterial Hypertension, 2017, Vol. 23, no. 5, pp. 457-467. (In Russ.)]
Борукаева И.Х., Абазова З.Х., Иванов А.Б., Мисирова И.А., Шхагумов К.Ю., Шаваева Ф.В., Молов А.А., Кипкеева Т.Б., Шокуева А.Г. Сохранение иммуномодулирующего действия интервальной гипокситерапии после коронавирусной инфекции в отдаленном периоде // Медицинская иммунология, 2023. Т. 25, № 4. С. 809-814. [Borukaeva I.Kh., Abazova Z.Kh., Ivanov A.B., Misirova I.A., Shkhagumov K.Yu., Shavaeva F.V., Mоlov A.A., Kipkeeva T.B., Shokueva A.G. Preservation of the immunomodulatory effect of interval hypoxytherapy after coronavirus infection in the long-term period. Meditsinskaya immunologiya = Medical Immunology (Russia), 2023, Vol. 25, no. 4, pp. 809-814. (In Russ.)] doi: 10.15789/1563-0625-POT-2767.
Борукаева И.Х., Абазова З.Х., Иванов А.Б., Шхагумов К.Ю. Интервальная гипокситерапия и энтеральная оксигенотерапия в реабилитации пациентов с хронической обструктивной болезнью легких // Вопросы курортологии, физиотерапии и лечебной физической культуры, 2019. Т. 96, № 2. С. 27-32. [Borukaeva I. Kh., Abazova Z.Kh., Ivanov A.B., Shkhagumov K.Yu. The role of interval hypoxytherapy and enteral oxygen therapy in the rehabilitation of the patients presenting with chronic obstructive pulmonary disease. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury = Issues of Balneology, Physiotherapy and Therapeutic Physical Culture, 2019, Vol. 96, no. 2, pp. 27-32. (In Russ.)]
Василец Л.М., Григориади Н.Е., Гордийчук Р.Н., Карпунина Н. С., Кривая А.А., Щербенев В.М. Особенности показателей системного воспаления у пациентов с артериальной гипертонией // Современные проблемы науки и образования, 2012. № 6. [Электронный ресурс]. Режим доступа: https://science-education.ru/ru/article/view?id = 7539 (дата обращения: 15.03.2024). [Vasilets L.M., Grigoriadi N.E., Gordiychuk R.N., Karpunina N.S., Krivaya A.A., Scherbenev V.M. Features of systemic inflammation indicators in patients with arterial hypertension. Sovremennye problemy nauki i obrazovaniya = Modern Problems of Science and Education, 2012, no. 6. [Electronic resource]. Access mode: https://science-education.ru/ru/article/view?id = 7539 (accessed on 15.03.2024). (In Russ.)]
Ваулин Н.А. Дисфункция эндотелия при артериальной гипертензии: фокус на небиволол // Системные гипертензии, 2009. № 1. С. 11-14. [Vaulin N.A. Endothelial dysfunction in arterial hypertension: focus on nebivolol. Sistemnyye gipertenzii = Systemic Hypertension, 2009, no. 1, pp. 11-14. (In Russ.)]
Гаврилюк Е.В., Конопля А.И., Караулов А.В. Роль иммунных нарушений в патогенезе артериальной гипертонии // Иммунология, 2016. Т. 37, № 1. С. 29-36. [Gavrilyuk E.V., Konoplya A.I., Karaulov A.V. Role of immune disturbances in the pathogenesis of the arterial hypertonia. Obzor. Immunologiya = Immunologiya, 2016, Vol. 37, no. 1, pp. 29-36. (In Russ.)]
Зиганшина М.М., Зиганшин А.Р., Халтурина Е.О., Баранов И.И. Артериальная гипертензия как следствие дисфункции эндотелиального гликокаликса: современный взгляд на проблему сердечно-сосудистых заболеваний // Кардиоваскулярная терапия и профилактика, 2022. Т. 21, № 9. 3316. [Ziganshina M.M., Ziganshin A.R., Khalturina E.O., Baranov I.I. Arterial hypertension as a consequence of endothelial glycocalyx dysfunction: a modern view of the problem of cardiovascular diseases. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular Therapy and Prevention, 2022, Vol. 21, no. 9, 3316. (In Russ.)] doi: 10.15829/1728-8800-2022-3316.
Пехова К.А., Михин В.П., Гаврилюк Е.В., Конопля А.И. Иммунометаболические нарушения при гипертонической болезни различной степени тяжести // Вестник новых медицинских технологий, 2012. Т.19, № 1. С. 172-173. [Pekhova K.A., Mikhin V.P., Gavrilyuk E.V., Konoplya A.I. Immune and metabolic disturbances at the idiopathic hypertensia of various severity level. Vestnik novykh meditsinskikh tekhnologiy = Journal of New Medical Technologies, 2012, Vol. 19, no. 1, pp. 172-173. (In Russ.)]
Свидовская С.В., Михалевская Н.А., Галченкова О.С., Князева Л.А. Провоспалительная цитокинемия и жесткость артериального русла при нефрогенной гипертензии // Вестник новых медицинских технологии, 2012. Т. 19, № 4. С. 126-127. [Svidovskaya S.V., Mikhalevskaya N.A., Galchenkova O.S., Knyazeva L.A. Proinflammatory cytokinemia and stiffness of the arterial channel in nephrogenic hypertension. Vestnik novykh meditsinskikh tekhnologiy = Journal of New Medical Technologies, 2012, Vol. 19, no. 4, pp. 126-127. (In Russ.)]
Хусаинова Л.Н., Исламгалеева З.М., Беляева И.Г., Мингазетдинова Л.Н., Муталова Э.Г. Экспрессия цитокиновой сети у больных с сердечно-сосудистыми заболеваниями // Успехи современного естествознания, 2013. № 3. С. 2-30. [Khusainova L.N., Islamgaleeva Z.M., Belyaeva I.G., Mingazetdinova L.N., Mutalova E.G. Expression of cytokine network in patients with cardiovascular diseases. Uspekhi sovremennogo yestestvoznaniya = Advances of Modern Natural Science, 2013, no. 3, pp. 2-30. (In Russ.)]
Bernardo R.I., Hector P., Jonson R.J. Role of the immune system in hypertension. Physiol. Rev., 2017, no. 97, pp. 1127-1164.
Jaquet V., Leidal K., Perozzo R., Plastre O., Fioraso-Cartier L., Diebold B., Scapozza L., Nauseef W.M., Krause K.H., Bedard K. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. Br. J. Pharmacol., 2011, no. 164, pp. 507-520.
Norlander A.E., Madhur M.S., Harrison D.G. The immunology of hypertension. J. Exp. Med., 2018, Vol. 215, no. 1, pp. 21-33.

补充文件

附件文件

动作

1. JATS XML

下载

用户名
密码
记住我

忘记您的密码?	注册

用户名
密码
记住我

忘记您的密码?	注册