EXPRESSION AND FUNCTIONAL ACTIVITY OF TLR2 AND TLR4 IN PATIENTS WITH ALLERGIC BRONCHIAL ASTHMA
- 作者: Khoreva M.1, Latisheva T.2, Ogurtsova A.1, Gracheva L.3, Zakharov M.3, Switich O.1, Gankovskaya L.1
-
隶属关系:
- Pirogov Russian National Research Medical University
- National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
- Russian Children’s Clinical Hospital
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 614-616
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120319
- DOI: https://doi.org/10.31857/S102872210006990-4
- ID: 120319
如何引用文章
全文:
详细
TLR2 and TLR4 expression and functional activity in peripheral blood mononuclear cell of patients with controlled allergic bronchial asthma were increased. TLR2 and TLR4 expression and functional activity in peripheral blood mononuclear cell were higher in patients with moderate asthma than in patients with mild asthma. The identifi ed changes may increase the susceptibility of patients to infectious agents and lead to complications.
作者简介
M. Khoreva
Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: markhoreva@yandex.ru
PhD, MD (Medicine), Professor of Department of Immunology, Faculty of Medical Biology,
Moscow
俄罗斯联邦T. Latisheva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head of the Department of Immunopathology and Intensive Therapy,
Moscow
俄罗斯联邦A. Ogurtsova
Pirogov Russian National Research Medical University
Email: fake@neicon.ru
assistant of Department of Immunology, Faculty of Medical Biology,
Moscow
俄罗斯联邦L. Gracheva
Russian Children’s Clinical Hospital
Email: fake@neicon.ru
PhD, MD (Medicine), Head of the Laboratory of Clinical Immunology,
Moscow
俄罗斯联邦M. Zakharov
Russian Children’s Clinical Hospital
Email: fake@neicon.ru
Ph.D., Head of the Department of blood transfusion and gravitational surgery,
Moscow
俄罗斯联邦O. Switich
Pirogov Russian National Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Corresponding Member of the Russian Academy of Sciences, Professor of Department of Immunology, Faculty of Medical Biology,
Moscow
俄罗斯联邦L. Gankovskaya
Pirogov Russian National Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head of the Department of Immunology, Faculty of Medical Biology,
Moscow
俄罗斯联邦参考
- He M., Ichinose T., Yoshida Y., Arashidani K., Yoshida S., Takano H., Sun G., Shibamoto T. Urban Pm2.5 Exacerbates Allergic Inflammation In The Murine Lung Via A Tlr2/Tlr4/Myd88-Signaling Pathway. Sci Rep 2017, 7 (1), 1–9.
- Athari S. S., Athari S. M., Beyzay F., Movassaghi M., Mortaz E., Taghavi M. Critical Role Of Toll-Like Receptors In Pathophysiology Of Allergic Asthma Eur J Pharmacol, 2017, Vol. 808, p. 21–27.
- Ковальчук Л. В., Хорева М. В., Никонова А. С. Распознающие рецепторы врожденного иммунитета (NLR, RLR И CLR) // Журнал микробиологии, эпидемиологии и иммунобиологии, 2011. No 1. С. 93–100.
- Bezemer G. F., Sagar S., van Bergenhenegouwen J., Georgiou N. A., Garssen J., Kraneveld A. D., Folkerts G. Dual role of Toll-like receptors in asthma and chronic obstructive pulmonary disease. Pharmacol. Rev., 2012, no. 64, pp. 337–358.
