ALTERNATIVE WAYS TO ACTIVATE THE CHEMOTAXIS OF ACUTE MYELOID LEUKEMIA CELLS
- 作者: Filina A.1,2, Svitich O.1,2, Golenkov A.3, Klinushkina E.3, Zverev V.1,2
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隶属关系:
- Mechnikov Research Institute of Vaccines and Sera
- First Moscow I. M. Sechenov State Medical University
- SBHI of MA MRRCI n. a. M. F. Vladimirskiy
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 596-598
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120313
- DOI: https://doi.org/10.31857/S102872210006986-9
- ID: 120313
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详细
One of the main factors of innate immunity involved in tumor progression and metastasis are TLRs, ligands of TLRs, chemokines and their receptors. The relationship between the above factors and the oncological process was studied not revrntly, but the last decade has been actively studied by scientists from all over the world. Despite the great interest in this issue, a more detailed study so far concerns only a few chemokines, such as CXCL12, CCL8 and their receptors, as well as TLRs and their ligands. Thus, in our work, we wanted to explore possible options for mediated chemotaxis of leukemia cells, as well as the eff ect of heterologous receptor activation on each other.
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作者简介
A. Filina
Mechnikov Research Institute of Vaccines and Sera;First Moscow I. M. Sechenov State Medical University
编辑信件的主要联系方式.
Email: byzonka@yandex.ru
Junior Researcher, Laboratory of Molecular Immunology,
Moscow
俄罗斯联邦O. Svitich
Mechnikov Research Institute of Vaccines and Sera;First Moscow I. M. Sechenov State Medical University
Email: fake@neicon.ru
Cor. Memb. RAS, Ph D., director of the Mechnikov Research Institute of Vaccines and Sera,
Moscow
俄罗斯联邦A. Golenkov
SBHI of MA MRRCI n. a. M. F. Vladimirskiy
Email: fake@neicon.ru
PhD, professor, hematologist, head of the clinic of clinical hematology and immunotherapy,
Moscow
俄罗斯联邦E. Klinushkina
SBHI of MA MRRCI n. a. M. F. Vladimirskiy
Email: fake@neicon.ru
hematologist, head of the department of clinical hematology and immunotherapy,
Moscow
俄罗斯联邦V. Zverev
Mechnikov Research Institute of Vaccines and Sera;First Moscow I. M. Sechenov State Medical University
Email: fake@neicon.ru
PhD, Academician of RAS, DSc, Scientifi c Director of the Research,
Moscow
俄罗斯联邦参考
- Mills S. C., Goh P. H., Kudatsih J., Ncube S., Gurung R., Maxwell W., & Mueller A. (2016). Cell migration towards CXCL12 in leukemic cells compared to breast cancer cells. Cellular Signalling, 28(4), 316–324
- Pradere J. P., Dapito D. H., & Schwabe R. F. (2013). The Yin and Yang of Toll-like receptors in cancer. Oncogene, 33(27), 3485–95.
- Webb R. N., Cruse J. M., & Lewis R. E. (2007). Differential cytokine and Toll-like receptor expression in leukemia. Experimental and Molecular Pathology, 83(3), 464–470.
