THE EFFECT OF ALLOIMMUNIZATION BY HUMAN LYMPHOCYTES ON THE PROLIFERATIVE ACTIVITY OF WOMAN CELLS WITH A HIGH FREQUENCY OF HLA SHARING
- 作者: Fedorova A.1, Khonina N.2
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隶属关系:
- «Новосибирский национальный исследовательский государственный университет»
- Federal Budget Institution of Science «Research Institute of fundamental and clinical immunology»
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 593-595
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120312
- DOI: https://doi.org/10.31857/S102872210006985-8
- ID: 120312
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详细
The level of the proliferative response of female cells to partner antigens in women with a high degree of HLA sharing in couples is significantly lower than in women with no HLA similarity. The alloimmunization of the partner’s lymphocytes is accompanied by an increase in the proliferative response in all groups of women regardless of HLA sharing. However, woman with a high sharing of HLA antigens have a lower level of cell proliferation than woman with no sharing of HLA antigens.
作者简介
A. Fedorova
«Новосибирский национальный исследовательский государственный университет»
编辑信件的主要联系方式.
Email: fake@neicon.ru
MD, PhD, Leading Researcher of the Laboratory of Сell Immunotherapy,
Novosibirsk
俄罗斯联邦N. Khonina
Federal Budget Institution of Science «Research Institute of fundamental and clinical immunology»
Email: nkhonina@mail.ru
student,
Novosibirsk
俄罗斯联邦参考
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- Cavalcante M. B., Sarno M., Niag M. Lymphocyte immunotherapy for recurrent miscarriages: Predictors of therapeutic success. Am J Reprod Immunol. 2018, 79: e12833. doi: 10.1111/aji.12833.
- Günther V., Alkatout I., Junkers W., Maass N., Ziemann M., Görg S., von Otte S. Active Immunisation with Partner Lymphocytes in Female Patients Who Want to Become Pregnant – Current Status. Geburtshilfe Frauenheilkd. 2018, l78, 260–273. doi: 10.1055/ s-0044-101609.
- Khonina N. A., Broitman E. V., Shevela E. Y., Pasman N. M., Chernykh E. R. Mixed lymphocyte reaction blocking factors (MRL-Bf) as potential biomarker for indication and efficacy of paternal lymphocyte immunization in recurrent spontaneous abortion. Arch Gynecol Obstet. 2013, 288, 933–7.doi: 10.1007/s00404-013-2832-x.
