FEATURES OF CYTOKINES, ADIPOKINES, MATRIX MATELOPROTEINASE-9 AND ITS INHIBITORSIMBALANCE, DEPENDING ON THE CLINICAL MANIFESTATIONS OF ATHEROSCLEROSIS
- 作者: Turmova E.1, Markelova E.1, Kiku P.2
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隶属关系:
- Federal State Budget Educational Institution of Higher Education «Pacific state medical university» Health Ministry of Russian Federation
- Federal State Autonomous Educational Institution of Higher Education «Far Eastern Federal University» (FEFU)
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 584-586
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120309
- DOI: https://doi.org/10.31857/S102872210006982-5
- ID: 120309
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140 patients with coronary atherosclerosis (CA), ischemic heart disease (IHD) and 120 people with obliterating atherosclerosis of lower extremities (OALE) were examined. The levels of IL-1β, IL-6, IFNγ, TNFα, IL-10, TGF-β1, TGF-β2, IL-2, IL-17, soluble cytokine receptors: IL-2R, IL- 6R, TNFα RI and TNFα RII, metalloproteinase-9 and its inhibitors (MMP-9, TIMP-1, MMP-9/TIMP-1, MMP-9/TIMP-2 complexes), adipokines (leptin and adiponectin) in serum. In patients with OALE, increase of IFNγ, TNFα, TN-α RII, IL-6 and TIMP-1 (p<0.05) was registered. By the factor analysis method, it was determined, that the IFNγ, IL-2, TNFα and IL-6 have leading pathogenetic significance in OALE. In patients with IHD, pathogenetic signifi cance and increase of the IL-1β, IL-17 and increase of the leptin was revealed.
作者简介
E. Turmova
Federal State Budget Educational Institution of Higher Education «Pacific state medical university» Health Ministry of Russian Federation
编辑信件的主要联系方式.
Email: eturmova@mail.ru
PhD, associate professor of the normal and pathological physiology department,
Vladivostok
俄罗斯联邦E. Markelova
Federal State Budget Educational Institution of Higher Education «Pacific state medical university» Health Ministry of Russian Federation
Email: fake@neicon.ru
PhD, professor, head of the normal and pathological physiology department,
Vladivostok
俄罗斯联邦P. Kiku
Federal State Autonomous Educational Institution of Higher Education «Far Eastern Federal University» (FEFU)
Email: fake@neicon.ru
Ph.D., professor of Biomedicine school (Preventive medicine department),
Vladivostok
俄罗斯联邦参考
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- Yetkin E., Ozturk S., Yetkin G. I. Inflammation in Coronary Artery Ectasia Compared to Atherosclerosis. Int. J. Mol. Sci. 2018, 19(10). E2971. doi: 10.3390/ijms19102971. (Типовая, англоязычная).