ANTIMICROBIAL PEPTIDES IN THE TREATMENT OF MUSCULAR ORAL CAVITY
- 作者: Sarkisyan N.1, Kataev N.1, Tuzankina I.2, Melikyan S.1
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隶属关系:
- Ural state medical university of the ministry of health of the Russian Federation
- Institute of Immunology and Physiology Ural detachment of the Russian Academy of Sciences
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 524-526
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120290
- DOI: https://doi.org/10.31857/S102872210006952-2
- ID: 120290
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全文:
详细
Antimicrobial peptides are the most promising drugs in the replacement of antibiotic therapy. The results of the analysis of the physicochemical properties of Atsegram spray, in particular, surface tension (σ, Erg / cm2) and conductivity (æ, μS / cm) show the relationship with the mechanism of the antibacterial action of the drug and its eff ectiveness in the treatment of periodontitis. Spray application revealed an improvement in the hygienic condition of the oral cavity by a factor of 1.4, a decrease in the PMA index by 1.8 times, a decrease in the bleeding index of the gingival margin by a factor of 2 a month after treatment compared with the same indicators of the comparison group undergoing standard treatment.
作者简介
N. Sarkisyan
Ural state medical university of the ministry of health of the Russian Federation
编辑信件的主要联系方式.
Email: narine_25@mail.ru
candidate of medical sciences, assistant, department of therapeutic dentistry and propedeutics of dental diseases,
Ekaterinburg
俄罗斯联邦N. Kataev
Ural state medical university of the ministry of health of the Russian Federation
Email: fake@neicon.ru
candidate of chemical sciences, assistant professor department of general chemistry,
Ekaterinburg
俄罗斯联邦I. Tuzankina
Institute of Immunology and Physiology Ural detachment of the Russian Academy of Sciences
Email: fake@neicon.ru
doctor of medicine, professor,
Ekaterinburg
俄罗斯联邦S. Melikyan
Ural state medical university of the ministry of health of the Russian Federation
Email: fake@neicon.ru
student,
Ekaterinburg
俄罗斯联邦参考
- Ронь Г. И. Инновационные технологии в диагностике и лечении воспалительных заболеваний пародонта. Екатеринбург, УГМА, 2011, 276 с.
- Мусин Х. Г. Антимикробные пептиды – потенциальная замена традиционным антибиотикам // Инфекция и иммунитет. 2018.Т.8, № 3.С.295–308.
- Слесарев В. И. Химия: Основы химии живого. Учебник для вузов, Химиздат, 2017, 784 с.
- Hancock R. E.W., Sahl H.-G. Antimicrobial and hostdefense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol., 2006, vol. 24, pp. 1551–1557. doi: 10.1038/nbt1267
