EVALUATION OF VASCULAR ENDOTHELIAL FACTORS IN WOMEN WITH SELECTIVE DELAY OF FETUS GROWTH DURING MONOCHORIAL PREGNANCY

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The urgency of the problem of monochorial multiple pregnancy is due to the significant frequency of development of selective intrauterine growth-restricted (sIUGR) of the fetus.

Objective: To evaluate the features of angiogenesis in women with fetal sIUGR during monochorial pregnancy. 46 pregnant women with monochorial diamniotic twins were examined: 21 women with fetal sIUGR and 25 women without gestational complications. It has been established that the implementation of fetal sIUGR in monochorial pregnancy is caused by an imbalance of the main regulators of angiogenesis, endothelial dysfunction and a decrease in the number of endothelial progenitor cells, which leads to a violation of the stabilization and integrity of the vascular endothelium. 

作者简介

I. Remizova

Ural Scientific Research Institute of Maternity and Child Care

编辑信件的主要联系方式.
Email: RemizovaII@yandex.ru

Ph.D., Senior Researcher Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,

Yekaterinburg

俄罗斯联邦

G. Chistyakova

Ural Scientific Research Institute of Maternity and Child Care

Email: omm@niiomm.ru

MD, Professor, Head of the Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,

Yekaterinburg

俄罗斯联邦

A. Aitov

Ural Scientific Research Institute of Maternity and Child Care

Email: omm@niiomm.ru

correspondence postgraduate student,

Yekaterinburg

俄罗斯联邦

参考

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  3. Чистякова Г. Н., Ремизова И. И., Каюмова А. В., Данькова И. В., Мелкозерова О. А. Маркеры дисфункции эндотелия в прогнозировании плацентарной недостаточности с ранних сроков беременности, индуцированной вспомогательными репродуктивными технологиями. Проблемы репродукции. 2017, 6, 11–15.
  4. Yzydorczyk C., Armengaud J.B., Peyter A.C., Chehade H., Cachat F., Juvet C., Siddeek B., Simoncini S., Sabatier F., Dignat-George F., Mitanchez D., Simeoni U. Endothelial dysfunction in individuals born after fetal growth restriction: cardiovascular and renal consequences and preventive approaches. J. Dev. Orig. Health. Dis. 2017, 8(4), 448–464.
  5. Attar A., Monabati A., Parsanezhad M.E.. Endothelial progenitor cell subsets and preeclampsia: Findings and controversies. J Chin Med Assoc. 2017, 80(10), 615–622.

版权所有 © Remizova I.I., Chistyakova G.N., Aitov A.E., 2019

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