SPONTANEOUS AND STIMULATED AMOUNT OF REGULATORY T-CELLS AND ACTIVATED T-HELPERS IN CHILDREN WITH DIFFERENT ACTIVITY OF JUVENILE IDIOPATHIC ARTHRITIS
- 作者: Pashnina I.1,2
-
隶属关系:
- Regional Children’s Clinical Hospital
- Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 465-467
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120263
- DOI: https://doi.org/10.31857/S102872210006931-9
- ID: 120263
如何引用文章
全文:
详细
Children of 6‒17 years old with diff erent activity of juvenile idiopathic arthritis were examined: 42 with active arthritis, 11 with remission (with therapy), 10 children with persistent remission (without therapy) and 27 apparently healthy children. It was revealed by fl ow cytometry that after 24-hours incubation (37 °C, 5% СО2) the spontaneous and phytogemagglutinin-stimulated amount of regulatory T-cells (СD3+СD4+СD25+СD127) /neg) in all groups with juvenile idiopathic arthritis was decreased in comparison with healthy children. The number of activated T-helpers (СD3+СD4+СD25+СD127+) in all groups was the same.
作者简介
I. Pashnina
Regional Children’s Clinical Hospital;Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
编辑信件的主要联系方式.
Email: irina_pashnina@list.ru
PhD, Chief of Clinical Diagnostics Laboratory;
Researcher of Laboratory of Immunology of Inflammation,
Yekaterinburg
俄罗斯联邦参考
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- Sakaguchi S. Regulatory T Cells: History and Perspective. Methods in Molecular Biology 2011, 707, 3–17.
- Пашнина И. А. Субпопуляции Т-лимфоцитов у детей с различной активностью ювенильного идиопатического артрита. Российский иммунологический журнал. 2018, 12(21), 3, 391–395.
- Wei C.-M., Lee J.-H., Wang L.-C., Yang Y.-H., Chang L.-Y., Chiang B.-L. Frequency and phenotypic analysis of CD4+CD25+ regulatory T cells in children with juvenile idiopathic arthritis. Journal. of microbiology, immunology and infection 2008, 41, 1, 78–87.
