INFLUENCE OF FOCAL INFECTION ON THE CYTOKINE PROFILE IN PATIENTS WITH CHRONIC DERMATOSIS
- 作者: Patrushev A.1, Sukharev A.1, Nikitin V.1, Ivanov A.1, Sukhina I.1, Gumilevskaya O.1
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隶属关系:
- Military Medical Academy
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 455-458
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120257
- DOI: https://doi.org/10.31857/S102872210006928-5
- ID: 120257
如何引用文章
全文:
详细
The aim of the study was to assess the impact of focal infection foci (FI) on the cytokine profile of patients with psoriasis, lichen planus (LP) and atopic dermatitis (AD). The patients were divided into two groups: those with FI (psoriasis – 19 people, AD – 13 people, LP – 14 people) and those without FI (psoriasis – 17 people, AD – 11 people, LP – 13 people). The control group was also examined – 15 healthy individuals. Immunoenzyme method was used to determine the following cytokines in the blood serum of patients: IL-1β, IL-2, IL-4, IL-6, IL8, IL-10, TNF-α, INF-α, INF-γ. It was shown that on the background of the presence of FI, the content of IL-8 in blood serum significantly increased (in 89,5% of cases in patients with psoriasis, in 76,6% in LP patients and in 100% in patients with AD).
作者简介
A. Patrushev
Military Medical Academy
编辑信件的主要联系方式.
Email: alexpat2@yandex.ru
PhD, Assistant, Department of skin and venereal diseases,
St. Petersburg
俄罗斯联邦A. Sukharev
Military Medical Academy
Email: fake@neicon.ru
MD, Professor, Department of skin and venereal diseases,
St. Petersburg
俄罗斯联邦V. Nikitin
Military Medical Academy
Email: fake@neicon.ru
MD, Head of the immunological laboratory of the center for clinical laboratory diagnostics,
St. Petersburg
俄罗斯联邦A. Ivanov
Military Medical Academy
Email: fake@neicon.ru
MD, Professor, Head of Department of clinical biochemistry and laboratory diagnostics,
St. Petersburg
俄罗斯联邦I. Sukhina
Military Medical Academy
Email: fake@neicon.ru
PhD, Department of clinical biochemistry and laboratory diagnostics,
St. Petersburg
俄罗斯联邦O. Gumilevskaya
Military Medical Academy
Email: fake@neicon.ru
MD, Head of the center for clinical laboratory diagnostics,
St. Petersburg
俄罗斯联邦参考
- Фисун А. Я., Черкашин Д. В., Макиев Р. Г., Кириченко П. Ю. «Очаговая инфекция» – фактор риска или патогенетическая основа возникновения заболеваний системы кровообращения. Вестник Российской военно-медицинской академии. 2015, 3(51), 7–16.
- Патрушев А. В., Самцов А. В., Иванов А. М., Сухарев А. В., Асфендиаров Д. Д. Распространенность очагов хронической инфекции у больных Т-клеточноопосредованными дерматозами. Вестник дерматологии и венерологии. 2018, 94(3), 30–38.
