THE VASCULAR ENDOTHElial GROWTH FACTOR IN THE TREATMENT OF CHRONIC INFLAMMATORY PERIODONTAL DISEASES

Periodontal disease is associated with progressive loss of bone and soft periodontal tissue. The use of biodegradable hydrogel with vascular endothelial growth factor (VEGF) contributing to the settlement of scaff old by fi broblasts with the subsequent formation of Mature connective tissue of the periodontal ligament is promising. Examined and treated 10 patients in the Department of maxillofacial surgery UKH № 4. Comprehensive treatment included standard drug therapy and based on carboxymethylcellulose and VEGF. As a result of treatment, the concentration of pathogenic microflora of periodontium was signifi cantly reduced. The concentration of VEGF in the periodontal pocket decreases after the treatment and normal histoarchitectonics of the gingival mucosa was found. Immunohistochemical methods showed a decrease in extracellular secretion of VEGF, as well as the construction of fi bers not only from “young” collagen type III, but also collagen type I. This indicates a decrease in the activity of inflammation and activation of the plastic processes of the fi brous component, leading to the strengthening of the periodontal structures on the background of the treatment. Thus, not only stimulation of regeneration was noted, but also a pronounced anti-inflammatory eff ect of hydrogel with a vascular endothelial growth factor having the potential to stimulate regeneration of periodontal tissues.