THE ROLE OF TLR9 AND COMPONENTS OF THE INFLAMMASOMA COMPLEX IN IMMUNOPATHOGENESIS OF PSORIASIS
- 作者: Merkushova E.1, Khasanova E.1, Switich O.1, Batkaeva N.2, Gitinova M.2, Gankovskaya L.1
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隶属关系:
- Pirogov Russian National N. Pirogov Research Medical University
- Peoples’ Friendship University of Russia
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 406-408
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/120187
- DOI: https://doi.org/10.31857/S102872210006912-8
- ID: 120187
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详细
Psoriasis is an autoimmune disease in pathogenesis of which are involved autoinfl ammatory reaction too. An important role in the development of psoriatic infl ammation is given to the activation of infl ammasome. In this study, we investigate the expression of TLR9 genes, components of the infl ammasome complex (NLRP1, NLRP3), and eff ector molecules IL-1β and IL-18 in healthy and aff ected skin bioptates in 35 patients with severe psoriasis was studied using PCR-RT. In the psoriatic focus was found increasing the level expression of TLR9 genes 4.1 fold, NLRP1–6 fold. Analysis of interleukin gene expression revealed a 10-fold increase in IL-18 gene expression in the psoriatic focus, while IL-1β gene expression was comparable to its expression in healthy skin bioptates.
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作者简介
E. Merkushova
Pirogov Russian National N. Pirogov Research Medical University
编辑信件的主要联系方式.
Email: rina.karmin@outlook.com
assistant of Department of Immunology,
俄罗斯联邦
E. Khasanova
Pirogov Russian National N. Pirogov Research Medical University
Email: fake@neicon.ru
student of Medicobiologic Faculty,
俄罗斯联邦
O. Switich
Pirogov Russian National N. Pirogov Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Corresponding Member Russian Academy of Sciences, Assistant Professor,
俄罗斯联邦
N. Batkaeva
Peoples’ Friendship University of Russia
Email: fake@neicon.ru
PhD, Assistant Professor, Department of dermatovenerology and cosmetology,
俄罗斯联邦
M. Gitinova
Peoples’ Friendship University of Russia
Email: fake@neicon.ru
assistant of Department of dermatovenerology and cosmetology,
俄罗斯联邦
L. Gankovskaya
Pirogov Russian National N. Pirogov Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head, Department of Immunology,
俄罗斯联邦
参考
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- Maria L. Salskov-Iversen, Claus Johansen, Knud Kragballe and Lars Iversen. Caspase-5 Expression Is Upregulated in Lesional Psoriatic Skin Journal of Investigative Dermatology; 2011; V-131. 5. Chung Y., Chang S. H., Martinez G. J., Yang X. O., Nurieva R., Kang H. S., Ma L., Watowich S. S., Jetten A. M., Tian Q., Dong C. Critical regulation of early Th17 cell diff erentiation by interleukin-1 signaling. Immunity; 2009; 30:576–587.
