FEATURES OF CONGENITAL IMMUNITY OF PREMATURE INFANTS WITH SEVERE HYPOXIC-ISCHEMIC LESIONS OF THE CENTRAL NERVOUS SYSTEM
- 作者: Chistyakova G.1, Ustyantsev L.1, Remizov I.1
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隶属关系:
- FGBU “Ural Scientific Research Institute for Maternal and Infant Childhood Protection", Ministry of Health of the Russian Federation
- 期: 卷 20, 编号 3 (2017)
- 页面: 564-566
- 栏目: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/120076
- ID: 120076
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详细
With the purpose of revealing the features of the innate immunity of premature infants with severe hypoxic-ischemic injury of the central nervous system, depending on the gestational age, a survey of deeply preterm infants born at the time of very early and early premature births was conducted. It was established that in all premature infants with severe hypoxic-ischemic CNS lesions, the level of expression of adhesion molecules on monocytes (CD14+CD11b+) and an increase in the level of IFN-γ and IL-8 at birth was observed at birth, regardless of the gestational age. The peculiarity of the immune response of children born in the term of early premature births is a decrease in the relative number of activated monocytes of CD14+CD64+ and CD14+HLA-DR, which indicates a disruption in the relationship between the cells of congenital and adaptive immunity and may be the cause of bacterial complications and a prolonged course of inflammatory Process.
作者简介
G. Chistyakova
FGBU “Ural Scientific Research Institute for Maternal and Infant Childhood Protection", Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: noemail@neicon.ru
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L. Ustyantsev
FGBU “Ural Scientific Research Institute for Maternal and Infant Childhood Protection", Ministry of Health of the Russian Federation
Email: noemail@neicon.ru
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I. Remizov
FGBU “Ural Scientific Research Institute for Maternal and Infant Childhood Protection", Ministry of Health of the Russian Federation
Email: noemail@neicon.ru
俄罗斯联邦
参考
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- Чистякова Г. Н., Ремизова И. И., Газиева И. А., Бычкова С. В., Занина Е. В., Чарипова Б. Т. Про-и противовоспалительные медиаторы у новорожденных с перинатальной патологией. Российский вестник перинатологии и педиатрии 2014, 59(2), 66-70.
- Каракушикова А. С., Рахимова К. В., Абдуллаева Г. М. Особенности иммунного статуса недоношенных детей с перинатальной патологией в раннем неонатальном периоде. Педиатрия 2012, 91(1), 21-25