CYTOKINE PROFILE IN PATIENTS WITH ASEPTIC NECROSIS OF THE FEMORAL HEAD
- 作者: Chekushkin A.V.1, Safronov A.A.1, Safronof A.A.1, Filippova Y.V.1, Matiyash A.M.1
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隶属关系:
- SEIHPE Orenburg State Medical University, Ministry of Health of Russia
- 期: 卷 20, 编号 3 (2017)
- 页面: 557-559
- 栏目: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/120035
- ID: 120035
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全文:
详细
The levels of serum cytokines were investigated in 17 patients with aseptic necrosis of the femoral head before surgery total joint replacement aged between 33 and 57. A significant increase in the blood compared to normal levels of TNF-α, IL-17, IL - 4, IL-10 as well as the decrease of IFN-γ was determined. The identified imbalance of cytokines which are positively and negatively regulating the osteoclastogenesis may contribute to an increased resorption of bone tissue in this pathology.
作者简介
A. Chekushkin
SEIHPE Orenburg State Medical University, Ministry of Health of Russia
编辑信件的主要联系方式.
俄罗斯联邦
A. Safronov
SEIHPE Orenburg State Medical University, Ministry of Health of Russia俄罗斯联邦
Al. Safronof
SEIHPE Orenburg State Medical University, Ministry of Health of Russia俄罗斯联邦
Y. Filippova
SEIHPE Orenburg State Medical University, Ministry of Health of Russia俄罗斯联邦
A. Matiyash
SEIHPE Orenburg State Medical University, Ministry of Health of Russia俄罗斯联邦
参考
- Komori T. Cell Death in Chondrocytes, Osteoblasts, and Osteocytes. Int. J. Mol. Sci. 2016, Vol. 17, № 12, pii: E 2045.
- Ginaldi L., De Martinis M. Osteoimmunology and Beyond. Cur. Medicinal Chemistry 2016, Vol. 23, № 33, 3754-3774.
- Матвеичев А. В., Талаев В. Ю., Евплова И. А. Физиология и функционирование Т-хелперов 17-го типа. Успехи современной биологии 2016, Т. 136, № 3, 285-300.
- Чекушкин А. В., Сафронов А. А., Сафронов А. А. и др. Особенности иммунного статуса у пациентов с асептическим некрозом головки бедренной кости. Российский иммунологический журнал 2016, Т. 10 (19), № 2 (1), 248-250.
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