HORIONIC GONADOTROPIN IN REGULATION OF THE FUNCTIONAL ACTIVITY OF T-REGULATORY LYMPHOCYTES
- 作者: Zamorina S.1,2
-
隶属关系:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Perm State National Research University
- 期: 卷 20, 编号 2 (2017)
- 页面: 319-321
- 栏目: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/120015
- ID: 120015
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详细
The effect of human chorionic gonadotropin (HCG) on apoptosis and production of IL-10 and TGF-β1 by isolated pools of natural T-regulatory lymphocytes (nTreg, CD4+CD25bright) and precursors of adaptive Treg (aTreg, CD4+CD25-) in the in vitro system was studied. As a result, we demonstrated that HCG induces apoptosis of nTreg and interferes with aTreg apoptosis, without affecting the production of IL-10 and TGF-β1 by these cells.
作者简介
S. Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University
编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Nagirnaja L., Venclovas C., Rull K. et al. Structural and functional analysis of rare missense mutations in human chorionic gonadotrophin β-subunit. Mol. Hum. Reprod. 2012, 18, 379-390.
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- Schumacher A., Brachwitz N., Sohr S. et al. Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J. Immunol. 2009, 182, 5488-5497.
- Заморина С. А., Ширшев С. А. Хорионический гонадотропин - фактор индукции иммунной толерантности при беременности. Иммунология 2013, 34(2), 105-107.
- Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2004, 299, 1057-1061.
