MOLECULAR MODELLING OF FLAVONOID QUERCETIN TARGETING TO THE TOLL-LIKE RECEPTORS
- 作者: Zaitsev V.1, Zheltova A.2, Nikonenko A.1
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隶属关系:
- Volgograd State University
- Volgograd State Medical University
- 期: 卷 20, 编号 2 (2017)
- 页面: 317-319
- 栏目: Articles
- URL: https://journals.rcsi.science/1028-7221/article/view/120006
- ID: 120006
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全文:
详细
Molecular modelling of quercetin targeting to the extracellular and cytosolic domains of human Tolllike receptors (TLR1-TLR10) was performed. We showed that quercetin can be targeted to various TRLs preferably either in extracellular domain sites (TLR4, TLR5, TLR7, TLR8) or in cytosolic domain sites (TLR1-TLR2, TLR2-TLR6).
作者简介
V. Zaitsev
Volgograd State University
编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦
A. Zheltova
Volgograd State Medical University
Email: noemail@neicon.ru
俄罗斯联邦
A. Nikonenko
Volgograd State University
Email: noemail@neicon.ru
俄罗斯联邦
参考
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- Bhaskar S., Helen A. Quercetin modulates toll-like receptor-mediated protein kinase signaling pathways in oxLDL-challenged human PBMCs and regulates TLR-activated atherosclerotic inflammation in hypercholesterolemic rats. Mol. Cell. Biochem. 2016, 423(1-2), 53-65.
- Chen Y. C. Beware of docking! Trends Pharmacol. Sci. 2015, 36(2), 78-95.
