THE ANALYSIS OF PERIPHERAL BLOOD CYTOKINES IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION

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The level of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IFNγ, TNFα, GM-CSF in the peripheral blood of women with recurrent spontaneous abortion and uncomplicated pregnancy was investigated at 5–12 weeks of gestation. It was established, that the serum level of IL-1β, IL-22, IL-23 and IL-27 in women with habitual abortion increased, and the tendency to the elevation of serum level of IL-10 и IL-13 was seen.

作者简介

N. Kroshkina

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia

Email: fake@neicon.ru

PhD, researcher of the laboratory of clinical immunology,

Ivanovo

俄罗斯联邦

A. Kust

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia

编辑信件的主要联系方式.
Email: niimid.immune@mail.ru

postgraduate Student of the laboratory of clinical immunology,

Ivanovo

俄罗斯联邦

E. Kozelkova

Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia

Email: fake@neicon.ru

postgraduate Student of the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Reanimatology,

Ivanovo

俄罗斯联邦

参考

  1. Zhao X., Jiang Y., Wang L., Li Z., Li Q., Feng X. Advances in understading the immune imbalance between T-lymphocyte subsets and NK cells in recurrent spontaneous abortion. Geburtshilfe Fraunheilkd. 2018, 78(7), 677–683.
  2. Southcombe J., Tannetta D., Redman C., Sargent I. The immunomodulatory role of syncytiotrophoblast microvesicles. PLos One. 2011, 6(5): e20245.
  3. Батрак Н. В., Малышкина А. И., Сотникова Н. Ю., Крошкина Н. В. Урогенитальная инфекция как фактор риска рецидивирующих потерь беременности. Российский иммунологический журнал. 2015, 9(18); 1(1), 19–20. [Batrak N. V., Malyshkina A. V., Sotnikova N. Yu., Kroshkina N. V. Urogenital infection as risk factor of recurrent miscarriage. Russian Journal of Immunology. 2015, 9(18); 1(1), 19–20].
  4. Caprioli F., Sarra M., Caruso R., Stolfi C., Fina D., Sica G., MacDonald T. T., Pallone F., Monteleone G. Autocrine regulation of IL-21 production in human T lymphocytes. J Immunol. 2008, 180(3), 1800–1807.
  5. Zotos D., Coquet J. M., Zhang Y., Light A., D’Costa K., Kallies A., Corcoran L. M., Godfrey D. I., Toellner K. M., Smyth M. J., Nutt S. L., Tarlinton D. M. IL-21 regulates germinal center B cell diff erentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med. 2010, 207(2), 365–378.

版权所有 © Kroshkina N.V., Kust A.V., Kozelkova E.V., 2019

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