DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF HLA-DRB1-TNFA-308 IN PATIENTS WITH ULCERATIVE COLITIS OF THE RUSSIAN POPULATION OF CHELYABINSK REGION

The analysis of the distribution of HLA-DRB1-TNFA-308 two-locus haplotypes frequencies in patients with ulcerative colitis (UC) of the Russian population of the Chelyabinsk region is carried out in this article. The 19 haplotypes were identified, among which 4 haplotypes, containing -308*G TNFA allele, were characterized by high incidence rates in groups of UC patients and healthy individuals. A peculiarity of the UC patient group was the presence of two haplotypes containing the rare allele with the substitution -308*A TNFA: HLA DRB1* 01-TNFA-308*A; HLA DRB1* 13 -TNFA-308*A. These haplotypes were not found in the comparison group of healthy individuals. These haplotypes can be considered as markers of susceptibility to ulcerative colitis in the Russian Chelyabinsk region.

неспецифический язвенный колит, HLA, TNFA, ulcerative colitis, HLA, TNFA