Immunobiochemical markers of the gematoentsefalitics barrier and autosensibilization at early forms chronic ischemia of the brain
- 作者: Davydova E.1,2, Zurochka A.3,4, Altman D.1,2
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隶属关系:
- South Ural State Medical University
- Chelyabinsk Regional Clinical Hospital
- South Ural State University (National Research University)
- Federal State Institution of Science Institute of Immunology and Physiology
- 期: 卷 21, 编号 3 (2018)
- 页面: 261-267
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119850
- DOI: https://doi.org/10.31857/S102872210002392-6
- ID: 119850
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详细
The level of neurospecifi c proteins and autoantibodies to the subunit NR2 of the NMDA receptor in veterans with early forms of chronic cerebral ischemia was studied. It was shown that these patients had permeability disturbances of the blood-brain barrier with the growth of autosensibilization processes to brain antigens, which may be one of the mechanisms of progression of chronic cerebral ischemia and a predicted failure of cerebral circulation compensation in patients with progressive course of chronic cerebral ischemia. On the other hand, the defi nition of neurospecifi c proteins in the systemic circulation may be promising for the diagnosis of early stages of chronic cerebral ischemia, when other objective methods of research may be of little informative.
作者简介
E. Davydova
South Ural State Medical University; Chelyabinsk Regional Clinical Hospital
编辑信件的主要联系方式.
Email: noemail@neicon.ru
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A. Zurochka
South Ural State University (National Research University); Federal State Institution of Science Institute of Immunology and Physiology
Email: noemail@neicon.ru
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D. Altman
South Ural State Medical University; Chelyabinsk Regional Clinical Hospital
Email: noemail@neicon.ru
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参考
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- P. M. Bokesch, G. A. Izykenova, J. B. Justice, [et al.] NMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients. // Stroke. 2006. Vol. 37. P. 1432–1436.
- Давыдова Е. В. Определение аутоантител к субъединице NR2 глутаматного рецептора NMDA у ветеранов Афганистана с ранними формами хронической ишемии мозга / Е. В. Давыдова // Российский иммунологический журнал. 2016, 10 (19), 3, 241–243.
- J. D. Weissman, G. A. Khunteev, R. Heath, [et al.] NR2 antibodies: risk assessment of transient ischemic attack (TIA)/stroke inpatients with history of isolated and multiple cerebrovascular events // J. Neurol Sci. 2011, 300,1–2, 97–102.
