TUMOR NECROSIS FACTOR IN REGENERATION OF DEEP SKIN WOUNDS IN MICE
- 作者: Nosenko M.1,2, Ambaryan S.2, Nedospasov S.1,2, Drutskaya M.1
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隶属关系:
- Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
- Lomonosov Moscow State University
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 876-878
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119805
- DOI: https://doi.org/10.31857/S102872210006641-0
- ID: 119805
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Mechanisms of skin wound healing have been extensively studied in order to propose novel approaches for treatment of chronic and poorly healing wounds, including those associated with autoimmune pathologies, as well as for fibrosis prevention. Recent studies indicate the key role of proinfl ammatory cytokines, such as TNF, IL-6 and IL-1, in regulating skin regeneration. In our work we investigated the impact of tumor necrosis factor (TNF) on healing of deep skin wounds in mice by employing reverse genetics approach. We found, that conditional knock-out of TNF gene specifically in macrophages results in delayed wound healing. However inactivation of TNF in all cell types does not aff ect wound regeneration dynamics. Moreover, genetic knock-out of TNF receptor I (TNFRI) results in accelerated wound healing. Thus, the results of our study suggest that TNF from diff erent cell types plays a dual role in skin regeneration probably refl ecting that both cellular source of TNF as well as receptor type on target cells are important.
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作者简介
M. Nosenko
Engelhardt Institute of Molecular Biology of Russian Academy of Sciences;Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: maxim-nosenko@yandex.ru
junior stuff scientist;
PhD student at immunology department biological faculty,
Moscow
俄罗斯联邦S. Ambaryan
Lomonosov Moscow State University
Email: fake@neicon.ru
master student;
immunology department biological faculty,
Moscow
俄罗斯联邦S. Nedospasov
Engelhardt Institute of Molecular Biology of Russian Academy of Sciences;Lomonosov Moscow State University
Email: sergei.nedospasov@gmail.com
Academician of RAS, PhD, head of the lab,
Moscow
俄罗斯联邦M. Drutskaya
Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
Email: fake@neicon.ru
PhD, leading stuff scientist,
Moscow
俄罗斯联邦参考
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- Ansell D. M., Holden K. A., Hardman M. J. (2012) Animal models of wound repair: Are they cutting it? Exp Dermatol. 21,581–585.
- Wang X., Ge J., Tredget E. E., Wu Y. (2013) The mouse excisional wound splinting model, including applications for stem cell transplantation. Nat Protoc. 8,302– 309.