EFFECT OF PREGNANCY-SPECIFIC β1-GLYCOPROTEIN ON CHEMOKINE PROFILE OF CULTURED T-HELPER AND MONONUCLEAR CELLS
- 作者: Zamorina S.1, Litvinova L.2, Yurova K.2, Khaziakhmatova O.2, Timganova V.1, Bochkova M.1, Khramtsov P.1,2, Rayev M.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Immanuel Kant Baltic Federal University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 257-259
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119695
- DOI: https://doi.org/10.31857/S102872210006593-7
- ID: 119695
如何引用文章
全文:
详细
The effect of human pregnancy-specific β1-glycoprotein (PSG) on the production of chemokines by intact mononuclear cells and monocultures of CD4+ cells in vitro by Bio-Plex® multiplex immunoassay technology was studied. It has been established that PSG suppresses the production of IL-8, MIP-1α, MIP-1β, RANTES and MCP-1, chemokines, an elevated level of which is associated with spontaneous abortion. As a result, it can be concluded that PSG forms the fetoprotective chemokine profile of the studied immune cells.
作者简介
S. Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS
编辑信件的主要联系方式.
Email: mantissa7@mail.ru
PhD, MD (Biology), leading researcher,
Perm
俄罗斯联邦L. Litvinova
Immanuel Kant Baltic Federal University
Email: fake@neicon.ru
PhD, MD (Medicine), Head, Basic Laboratory of Immunology and Cell Biotechnologies,
Kaliningrad
俄罗斯联邦K. Yurova
Immanuel Kant Baltic Federal University
Email: fake@neicon.ru
PhD (Medicine), Researcher,
Kaliningrad
俄罗斯联邦O. Khaziakhmatova
Immanuel Kant Baltic Federal University
Email: fake@neicon.ru
Kaliningrad 俄罗斯联邦
V. Timganova
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, junior researcher,
Perm
俄罗斯联邦M. Bochkova
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, researcher,
Perm
俄罗斯联邦P. Khramtsov
Institute of Ecology and Genetics of Microorganisms UB RAS;Immanuel Kant Baltic Federal University
Email: fake@neicon.ru
PhD, researcher, Perm;
researcher, Kaliningrad
俄罗斯联邦M. Rayev
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: fake@neicon.ru
PhD, MD, Leading Researcher,
Perm
俄罗斯联邦参考
- Du M.-R., Wang S. C., Li D. J. The integrative roles of chemokines at the maternal-fetal interface in early pregnancy // Cell. Mol. Immunol. 2014; 11(5): P. 438– 448.
- Раев М. Б. Способ выделения и очистки трофобластического β-1-гликопротеина. Патент РФ № 2367449 от 20.09.2009. / «Изобретения. Полезные модели». – 2009. – № 26.
