THE ROLE OF THE MONOCYTIC AND MACROPHAGAL SYSTEM IN THE DYNAMICS OF THE REPLACEMENT REGENERATION IN CASE OF THE ELASTIN BIOMATERIAL TRANSPLANTATION

The article contains the results of the morphological investigations when subcutaneously transplanting two types of the elastin biomaterial: structurized and dispersed one (patent № 2440148). The experiments have been carried out on Wistar rats (n=59). The transplanted biomaterials were subjected to the stage-by-stage resorption with further formation of the connective tissue regenerate. When doing it, the cells of the macrophagal and fibroblastic differentiation come out as a unified morphofunctional system in which giant multinuclear cells are an indispensable element. Depending on the biomaterial structure there are singled out two histotopographic types of the replacement regeneration: frontal type for the structurized biomaterial and diffuse-locunar one for the dispersed biomaterial.

эластиновый биоматериал, макрофаги, гигантские многоядерные клетки, elastin biomaterial, macrophages, polynuclear cells