FEATURES OF DIFFERENTIATION OF DENDRITIC CELLS IN TYMUS IN CHILDREN DEPENDING ON TYPE OF CYANOSIS IN CONGENITAL HEART DISEASES

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The specific features of differentiation of dendritic cells (DC) of the thymus in children with depending on the type of cyanosis at congenital heart diseases (CHD) have been studied. It has been established that the accumulation of DC in the medullar and cortical compartment of the thymus occurs at CHD, especially in the case of blue types of CHD. When comparing the blue and white types of CHD, a change in the content of myeloid and plasmacytoid DC of the thymus was revealed. Thus, hypoxia affects the differentiation of the DC at thymus at CHD.

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N. Loginova

Perm State Medical University named after Academician E. A. Wagner

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E. Orlova

Institute of Ecology and Genetics of Microorganisms

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S. Shirshev

Institute of Ecology and Genetics of Microorganisms

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O. Loginova

Perm State Medical University named after Academician E. A. Wagner

Email: noemail@neicon.ru
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R. Shekhmametyev

Federal Center for Cardiovascular Surgery named after S. G. Sukhanov

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参考

  1. Дударев И. В. Иммунологическая и гемодинамическая характеристика детей с врожденными пороками сердца синего и бледного типа. Иммунология. 2002, 3, 167-170.
  2. Wu L., Shortman K. Heterogeneity of thymic dendritic cells. Semin. Immunol. 2005, 17, 304-312.
  3. Логинова Н. П. Особенности экспрессии FOXP3 и RORyt СD4+-тимоцитами у детей в зависимости от сложности врожденных пороков сердца. Биологические мембраны. 2016. Т. 33, № 1. С. 98-104.

版权所有 © Loginova N.P., Orlova E.G., Shirshev S.V., Loginova O.A., Shekhmametyev R.M., 2017

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