THE IMMUNOLOGICAL PREDICTORS OF THE INEFFICIENCY FIRST LINE THERAPY AT THE PRIMARY OPEN-ANGLE GLAUCOMA


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The primary open-angle glaucoma is a first in disability among eye diseases. First-line drugs – prostaglandin analogues are not always effective. The aim of the work was the search for predictors of the ineffectiveness of this therapy. The cytokines TNF-α, TNF-β, IL4, IL-6, IL-10, IL-13, IL-17, IL-22, IL-29, IFN-γ, TGF-α, TGF-β1, TGF -β2 was investigated in the tear fluid of 124 eyes in the diagnosis of glaucoma. Predictors of non-compensation of intraocular pressure when prescribing prostaglandin drugs is a high level of IL-17 and a decrease in TGF-β2. The high level of IL-6 is a predictor of a decrease in visual function during prostaglandin therapy.

作者简介

A. Kuznetsov

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

编辑信件的主要联系方式.
Email: agent_zebrovich@mail.ru

postgraduate student of Department of normal and pathological physiology,

Vladivostok

俄罗斯联邦

A. Khokhlova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

postgraduate student of Department of normal and pathological physiology,

Vladivostok

俄罗斯联邦

E. Markelova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

PhD, head of theDepartment of normal and pathological physiology,

Vladivostok

俄罗斯联邦

M. Urbanova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

resident of Department of ophthalmology and otorhinolaryngology, 

Vladivostok

俄罗斯联邦

N. Emeiyanova

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

student,

Vladivostok

俄罗斯联邦

A. Petrov

Federal State Educational Institution of Higher Education “Vladivostok State Medical University” of the Russian Federation Ministry of Health

Email: fake@neicon.ru

student,

Vladivostok

俄罗斯联邦

参考

  1. Астахов Ю. С., Нечипоренко П. А. Аналоги простагландинов: прошлое, настоящее, будущее. Офтальмологические ведомости, 2017, 10, 1, 40– 52.
  2. Симбирцев А. С. Роль цитокинов в развитии опухолей и в иммунотерапии рака. В кн.: Цитокины в патогенезе и лечении заболеваний человека. Фолиант, СПб 2018, 187–188.
  3. Duvesh R., Puthuran G., Srinivasan K. Multiplex Cytokine Analysis of Aqueous Humor from the Patients with Chronic Primary Angle Closure Glaucoma. Current Eye Research. 2017, 42, 1608–1613.
  4. Gupta D., Wen J., Huebner J. Cytokine biomarkers in tear film for primary open-angle glaucoma. Clinical Ophthalmology, 2017, 11, 411–416.
  5. Li T. Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis. Ophthalmology, 2016, 123(1), 129–140.

版权所有 © Kuznetsov A.S., Khokhlova A.S., Markelova E.V., Urbanova M.S., Emeiyanova N.P., Petrov A.A., 2019

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