THE LEVEL OF INTERLEUKIN17 AND INTERFERON γ IN CELL’S CULTURES SUPERNATANTS UNDER STIMULATION BY ANTIBODIES TO CD3 AND CD28 IN CHILDREN WITH ARTHRITIS OF DIFFERENT ETIOLOGY

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Children of 2–17 years old with juvenile idiopathic arthritis (n = 100), unspecified reactive arthropathy (n = 15) and 31 healthy children (controls) were examined. The spontaneous, anti-CD3-stimulated and anti-CD3/CD28-stimulated concentrations of IL-17 and IFN-γ in the cells cultures supernatants were determined by ELISA. The spontaneous IFN-γ level in children with arthritis of various etiologies was higher than in control, while the IFN-γ concentrations in both variants of stimulation in the patients were lower. The spontaneous IL-17 production in the patients and in healthy children was the same, while stimulated synthesis of IL-17 in the groups with arthritis was higher than in the control group.

作者简介

I. Pashnina

Regional Children’s Clinical Hospital

编辑信件的主要联系方式.
Email: irina_pashnina@list.ru

PhD, Head of clinical diagnostics laboratory,

 

俄罗斯联邦

I. Krivolapova

Regional Children’s Clinical Hospital

Email: fake@neicon.ru

biologist of clinical diagnostics laboratory,

 

俄罗斯联邦

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