COMPARATIVE ANALYSIS OF THE INFLUENCE OF RECTAL SUPPOSITORIA WITH CUCRUMIN ON THE CONCENTRATION OF IgG AND IgM IN BLOOD SERUM IN EXPERIMENTAL CROHN’S DISEASE

The use of anti-infl ammatory drugs (5-aminosalicylic acid (5-ASA), glucocorticoids) for Crohn’s disease (CD) as a basic therapy is limited to a wide range of side eff ects and requires the search of new therapeutic approaches. The aim of the work is to study the eff ect of rectal suppositories of the original composition with 80% spirituous extract of curcumin on the serum concentration of IgG and IgM in experimental CD. The work was performed on 70 Wistar white rats, CD was modeled by rectal administration of 100 μl of a 3% solution of trinitrobenzenesulfonic acid (TNBS), the extract of curcumin in rectal suppositories of the original composition based on polyethylene glycol was used every 12 hours, in the comparison group rectal suppositoria with 5-ASC were used every 12 hours also. The serum concentration of IgG and IgM was determined using specifi c test systems for rats on an immunoassay analyzer on 3, 5 and 7 days of the experiment. It was determined that in experimental TNBS-induced Crohn’s disease in the serum of rats, the concentration of IgG and IgM increases on days 3, 5 and 7 of the experiment. The use of curcumin extract in rectal suppositories of the original composition in experimental CD leads to a decrease in the concentration of IgG and IgM on days 3 and 5 of observation.

Crohn’s disease, Ig G, Ig M, curcumin, rectal suppositoria