STING ACTIVATION IN T CELLS LEADS TO UPR AND CELL DEATH

V. V. Ilyukha; Илюха В. В.; B. Larkin; Ларкин Б.; A. P. Prohorova; Прохорова А. П.; A. N. Poltorak; Полторак А. Н.

doi:10.31857/S102872210006699-3

STING ACTIVATION IN T CELLS LEADS TO UPR AND CELL DEATH

作者: Ilyukha V.¹, Larkin B.², Prohorova A.¹, Poltorak A.¹^,2
隶属关系:
1. Petrozavodsk State University
2. Department of Immunology, Tufts University Immunology Program, Boston
期: 卷 22, 编号 2-2 (2019)
页面: 784-785
栏目: ORIGINAL ARTICLES
URL: https://journals.rcsi.science/1028-7221/article/view/119578
DOI: https://doi.org/10.31857/S102872210006699-3
ID: 119578

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Despite well-studied role of the adapter STING in the cell response to cytosolic DNA, its contribution to the activation of programmed cell death was not considered at the proper level. In this study was shown that activation of STING in T cells leads to production of typeI interferons, upregulation expression levels of the interferon-stimulating gene group (ISG), as well as cell death. It is also shown that cell death is mediated by UPR (Unfolded Protein Response).