CROSS-LINKING ALLERGY IN BRONCHIAL ASTMA AND ALLERGEN-ASSOCIATED MOLECULAR PATTERNS (AAMP)

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To evaluate content of IL-4 in lymphoblast transformation test (LTT) supernatants of 15 persons with asthma, 16 patients with asthma in association with allergy to prawns and 15 healthy persons were studied. All sufferers of asthma were sensibilisized to Der p 1 (Dermatophagoides pteronissinus). There have not been revealed any differences between the IL-4 in different groups that may be indirectly propose the presence of Allergen-Associated Molecular Patterns (AAMPs) in patients, which might smooth out received results.

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V. Klimov

Siberian State Medical University

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V. Sviridova

Siberian State Medical University

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P. Isaev

Siberian State Medical University

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T. Koshovkina

Siberian State Medical University

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参考

  1. Pali-Scholl I., Jensen-Jarolim E. The concept of allergen-associated molecular patterns (AAMP). Current Opinion in Immunology. 2016, 42,113-118.
  2. Treanor B. B-cell receptor: from resting state to activate. Immunology. 2012, 136:21-27.
  3. Deak P. E., Vrabel M. R., Pizzuti V. J., et al. Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation. Exp Biol Med (Maywood). 2016, 241,996-1006.
  4. Шкатова А. Н. Динамика содержания ИЛ-4 у больных микогенными респираторными ал-лергозами при проведение специфической иммунотерапии. Вестник СГМУ (Томск) 2000, 1, 2, 93-94.

版权所有 © Klimov V.V., Sviridova V.S., Isaev P.Y., Koshovkina T.V., 2017

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