DEVELOPMENT OF MODELS OF HUMAN MALIGNANT TUMORS FOR CELLULAR IMMUNOTHERAPY

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Development of ectopic and orthotopic models of human malignant tumors in nude mice with consequent morphologic and immunologic studies was carried out. Morphologic compliancy of tumors having grown in mice to the initial ones was shown. Divergent immunologic changes were found in animals with ectopic and orthotopic tumors.

作者简介

E. Zlatnik

Federal Budget Institution Rostov Research Institute of Oncology

编辑信件的主要联系方式.
Email: elena-zlatnik@mail.ru

MD, Prof., Chief Researcher, Laboratory of Immunophenotyping of Tumors,

Rostov-on-Don

俄罗斯联邦

A. Maksimov

Federal Budget Institution Rostov Research Institute of Oncology

Email: fake@neicon.ru

MD., Professor, Deputy General Director for Advanced Scientific Developments,

Rostov-on-Don

俄罗斯联邦

A. Goncharova

Federal Budget Institution Rostov Research Institute of Oncology

Email: fake@neicon.ru

Ph D., Head of Experimental Laboratory Center,

Rostov-on-Don

俄罗斯联邦

N. Karnaukhov

Federal Budget Institution Rostov Research Institute of Oncology

Email: fake@neicon.ru

Ph D., Head of Department of Pathological Anatomy,

Rostov-on-Don

俄罗斯联邦

参考

  1. Трещалина Е. М. Иммунодефицитные мыши Balb/c Nude и моделирование различных вариантов опухолевого роста для доклинических исследований // Российский биотерапевтический журнал. – 2017. – Т. 16. – № . 3 – С. 6–13. doi: 10.17650/1726-9784-2017-16-3-6-13.
  2. Zhao X., Li L., Starr T. K., Subramanian S. Tumor location impacts immune response in mouse models of colon cancer. Oncotarget, 2017; 8(33): 54775–54787. doi: 10.18632/oncotarget.18423.
  3. Karasova D., Sebkova A., Havlickova H., Sisak F., Volf J., Faldyna M., Ondrackova P., Kummer V., Rychlik I. Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis. BMC Microbiol., 2010; 10: 75. Published online 2010 Mar 12 doi: 10.1186/1471-2180-10-75.

版权所有 © Zlatnik E.Y., Maksimov A.Y., Goncharova A.S., Karnaukhov N.S., 2019

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