FUNCTIONAL POLYMORPHISMS OF THE TNFα (G-308A), IL-1β (T-31C), IL-10 (C-592A) GENES AS FACTORS AFFECTING THE EFFECT OF CHEMOTHERAPY FOR ADVANCED OVARIAN CANCER
- 作者: Gening S.1, Abakumova T.1, Antoneeva I.1,2, Gening T.1, Dolgova D.1
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隶属关系:
- Ulyanovsk State University
- Ulyanovsk Regional Clinical Oncologic Dispensary
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 197-199
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119545
- DOI: https://doi.org/10.31857/S102872210006455-5
- ID: 119545
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全文:
详细
The paper discusses the role of a genetically determined imbalance in the cytokine network in assessing the eff ectiveness of platinum-containing chemotherapy in patients with serous ovarian adenocarcinoma. The frequency of functional polymorphisms of the cytokine IL-1β (T-31C), TNFα (G-308A), IL-10 (G-592A) genes was determined by qRT-PCR in control and in patients with advanced ovarian cancer. We studied the frequency distribution of alleles and genotypes of the IL-1β, TNFα, IL-10 genes in patients with OC in groups with relapses within a year after platinum-containing chemotherapy and without recurrence. The alleles -308G TNFα, -31T IL-1β, -592A IL-10 were found to be associated with disease progression or recurrence within 1 year after completion of treatment.
作者简介
S. Gening
Ulyanovsk State University
编辑信件的主要联系方式.
Email: fake@neicon.ru
postgraduate student, Department of Oncology and Radiology,
Ulyanovsk
俄罗斯联邦T. Abakumova
Ulyanovsk State University
Email: fake@neicon.ru
PhD, Associate Professor, Department of Physiology and Pathophysiology, Medical Faculty,
Ulyanovsk
俄罗斯联邦I. Antoneeva
Ulyanovsk State University;Ulyanovsk Regional Clinical Oncologic Dispensary
Email: fake@neicon.ru
MD, Professor, Department of Oncology and Radiology,
Ulyanovsk
俄罗斯联邦T. Gening
Ulyanovsk State University
Email: fake@neicon.ru
Doctor of Biological Sciences, Professor, Head of Department Physiology and Pathophysiology of the Medical Faculty,
Ulyanovsk
俄罗斯联邦D. Dolgova
Ulyanovsk State University
Email: dolgova.dinara@yandex.ru
Ph.D., Associate Professor, Department of Physiology and Pathophysiology, Medical Faculty,
Ulyanovsk
俄罗斯联邦参考
- Oliveira de J. G., Rossi A. F., Nizato D. M., Silva A. E. Profi les of Gene Polymorphisms in Cytokines and Toll-Like Receptors with Higher Risk for Gastric Cancer. Dig Dis Sci. 2013, 58, 978–988.
- Боброва О. П., Шнайдер Н. А., Петрова М. М., Зырянов С. К., Сычев Д. А. Генетический полиморфизм цитокинов как предиктор фенотипической реализации хронического болевого синдрома в онкологии. Сибирский онкологический журнал. 2017, 16(5), 87–94.
