CLINICAL ROLE OF LOCAL ANTIMICROBIAL FACTORS AND CYTOKINES IN CHILDREN WITH REACTIVE ARTHRITIS

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Significant local antimicrobial factors of the intestinal biotope and cytokines associated with the variant of the course of reactive arthritis (ReA): IL-17, IL-6, INF-γ, lysozyme, CRB have been determined, which allows them to be used as markers for predicting the course and the outcome of ReA.

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E. Danilova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

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I. Nikiforov

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

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O. Chelpachenko

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

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L. Fedotova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

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E. Ivanova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

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N. Perunova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

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T. Bondarenko

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

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参考

  1. Scher J. U., Littman D.R., Abramson S. B. Microbiome in inflammatory arthritis and human rheumatic diseases. Arthritis Rheumatol.2016, 68(1), 35-45.
  2. Vitetta L., Coulson S., Linnane A. W. et al. The gastrointestinal microbiome and musculoskeletal diseases: a beneficial role for probiotics and prebiotics. Pathogens 2013, 2, 606-626.
  3. O’Hara A.M., Shanahan F. Thegut flora as a forgotten organ. EMBO Rep. 2006, 7, 688-693.
  4. Челпаченко О.Е., Перунова Н.Б., Иванова Е. В. и со-авт. Локальные антимикробные факторы у детей с реактивным артритом. Российский иммунологический журнал 2016, 10(19), 2(1), 372-374.

版权所有 © Danilova E.I., Nikiforov I.A., Chelpachenko O.E., Fedotova L.P., Ivanova E.V., Perunova N.B., Bondarenko T.A., 2017

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